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Thiotrisescaline (T-TRIS) is a series of lesser-known phenethylamines prepared as potential psychedelic drugs. There are two isomers, 3-T-TRIS and 4-T-TRIS, each similar in structure to trisescaline with a sulfur atom in a place of a different oxygen atom. They were first synthesized by Alexander Shulgin and described in his book PiHKAL.[1][2] Very little is known about their dangers or toxicity.