Primrose syndrome
| Primrose syndrome | |
|---|---|
| Other names | Intellectual disability-cataracts-calcified pinnae-myopathy syndrome |
 | |
| Primrose syndrome is inherited via an autosomal dominant manner[1] | |
Primrose syndrome is a rare, slowly progressive genetic disorder that can vary symptomatically between individual cases, but is generally characterised by ossification of the external ears, learning difficulties, and facial abnormalities.[2] It was first described in 1982 in Scotland's Royal National Larbert Institution by Dr D.A.A. Primrose.[3]
Primrose syndrome appears to occur spontaneously, regardless of family history. The cause is currently unknown and there are no known treatments.[4]
Signs and symptoms
The common symptoms in all reported cases of primrose syndrome include ossified pinnae, learning disabilities or mental retardation, hearing problems, movement disorders (ataxia, paralysis, and parkinsonism among others (likely due, in part, to calcification of the basal ganglia), a torus palatinus (a neoplasm on the mouth's hard palate), muscle atrophy, and distorted facial features. Other symptoms usually occur, different in each case, but it is unknown whether or not these symptoms are caused by the same disease.[5]
Pathophysiology
The cause of Primrose syndrome is currently unknown. This condition is extremely rare and seems to spontaneously occur, regardless of family history.[5]
In the case studied by Dalai et al. in 2010, it was found that an abnormally high amount of calcitonin, a hormone secreted by the thyroid gland to stabilize blood calcium levels, was present in the blood serum. This suggests that the thyroid gland is releasing an abnormal amount of calcitonin, resulting in the disruption of calcium level homeostasis. No molecular cause was found, but an expanded microarray analysis of the patient found a 225.5 kb deletion on chromosome 11p between rs12275693 and rs1442927. Whether or not this deletion is related to the syndrome or is a harmless mutation is unknown. The deletion was not present in the patient's mother's DNA sample, but the father's DNA was unavailable.[4]
Diagnosis
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Management
Currently there are no known treatments.[4]
History
There have been very few reported cases of Primrose syndrome worldwide. The first known case was described by D.A. Primrose in 1982. The patient was a 33-year-old mentally retarded male whose outer ears had ossified. Additional symptoms included muscle atrophy in the legs and hands, deafness, cataracts, and a tissue mass covering the roof of his mouth.[3]
In 1986, Calacott et al. described a mentally handicapped patient whose pinnae had ossified. The patient also experienced deafness, cataracts, skeletal deformities, and muscle atrophy. As the second reported case of such symptoms, it suggested that these symptoms were part of one entity, named "Primrose syndrome"[6]
In 1996, Lindor et al. reported a 43-year-old male patient with schizophrenia, as well as other neurological disorders, and severe pinnae calcification. Additional symptoms included hearing loss, stiffened joints, and facial deformities.[7]
In 2006, Mathijssen et al. described an adult male mentally retarded patient who had calcified pinnae and a neoplasm of the palate. The patient also had extensive hearing loss, little to no body hair, distorted facial features, and joint contractures. The patient also developed testicular cancer, but it is unknown whether or not it is related to the syndrome. The patient experienced cryptorchidism, a birth defect where one of the testes is not present at birth, that may have played a part in the formation of the tumor.[8]
In 2010, another similar case was studied extensively by Dalal et al. The patient was a mentally retarded 43-year-old woman who had hearing impairment, distorted facial features, muscle atrophy, cataracts, and ossification of cartilage. Additionally, she was born with Ebstein malformation, a congenital heart defect, agenesis of the corpus callosum, and hip dysplasia. Other symptoms included hypothyroidism, diabetes, and muscle control problems. A brain MRI showed that her basal ganglia had partially calcified, which may have contributed to her paraparesis and motor tics.[4]
See also
References
- ^ "OMIM Entry - # 259050 - PRIMROSE SYNDROME; PRIMS". omim.org. Retrieved 6 August 2017.
- ^ Carvalho, D.R.; Speck-Martins, C.E. (June 2011). "Additional features of unique Primrose syndrome phenotype". American Journal of Medical Genetics. 155 (6): 1379–1383. doi:10.1002/ajmg.a.33955. PMID 21567911.
- ^ a b Primrose, D.A. (June 1982). "A slowly progressive degenerative condition characterized by mental deficiency, wasting of limb musculature and bone abnormalities, including ossification of the pinnae". Journal of Mental Deficiency Research. 26 (2): 101–6. doi:10.1111/j.1365-2788.1982.tb00133.x. PMID 6809950.
- ^ a b c d Dalal, P.; Leslie, N.D.; Lindor, N.M.; Gilbert, D.L.; Espay, A.J. (July 2010). "Motor tics, stereotypies, and self=flagellation in Primrose syndrome". Neurology. 75 (3): 284–286. doi:10.1212/wnl.0b013e3181e8e754. PMC 3463006. PMID 20644156.
- ^ a b "Primrose syndrome". Office of Rare Diseases Research. Retrieved 2011-09-01.
- ^ Collacott, R.A.; O'Malley, B.P.; Young, I.D. (September 1986). "The syndrome of mental handicap, cataracts, muscle wasting and skeletal abnormalities: Report of a second case". Journal of Intellectual Disability Research. 30 (3): 301–308. doi:10.1111/j.1365-2788.1986.tb01324.x. PMID 3783663.
- ^ Lindor, N.M.; Hoffman, A.D.; Primrose, D.A. (January 1996). "A neuropsychiatric disorder associated with dense calcification of the external ears and distal muscle wasting: 'Primrose syndrome'". Clinical Dysmorphology. 5 (1): 27–34. doi:10.1097/00019605-199601000-00004. PMID 8867656.
- ^ Mathijssen, Inge B.; Hasselt-van der Velde, Jos; Hennekam, Raoul C.M. (March 2006). "Testicular cancer in a patient with Primrose syndrome". European Journal of Medical Genetics. 49 (2): 127–133. doi:10.1016/j.ejmg.2005.06.001. PMID 16530709.