Nikkomycin
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Nikkomycins are a group of antifungal medications.[1] They work by interfering with the building of the fungal cell wall which results in the fungal cell breaking open.[1] They were discovered in 1976.[1] The specific agent nikkomycin Z has weak activity against Aspergillus fumigatus which may be of benefit when used with other medications,[1] such as caspofungin, ranconazole and amphotericin B, fluconazole or itraconazole.[2]
Originally identified from Streptomyces tendae, the nikkomycins are chitin synthase inhibitors.[2]
References
- ^ a b c d Steinbach, WJ; Stevens, DA (1 October 2003). "Review of newer antifungal and immunomodulatory strategies for invasive aspergillosis". Clinical Infectious Diseases. 37 Suppl 3: S157-87. doi:10.1086/376523. PMID 12975751.