Azaribine
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Trade names | Azaribine |
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ECHA InfoCard | 100.016.832 |
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Formula | C14H17N3O9 |
Molar mass | 371.3 g·mol−1 |
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Azaribine (triacetyl-6-azauridine) is a drug which was developed for the treatment of psoriasis,[1] and also has anti-cancer and antiviral actions.[2][3] It is a prodrug which is metabolised to the nucleoside analogue 6-azauridine in the body. Azaribine was approved for clinical use in treatment of psoriasis,[4] but subsequently withdrawn because of toxicity issues,[5][6] however it continues to be researched as a potential agent for the treatment of emerging viral diseases.[7]
References
- ^ Elis J, Rasková H (March 1972). "New indications for 6-azauridine treatment in man. A review". European Journal of Clinical Pharmacology. 4 (2): 77–81. doi:10.1007/bf00562501. PMID 4570456.
- ^ Creasey WA, Fink ME, Handschumacher RE, Calabresi P (March 1963). "Clinical and pharmacological studies with 2',3',5'-triacetyl-6-azauridine". Cancer Research. 23: 444–53. PMID 14023746.
- ^ Morrey JD, Smee DF, Sidwell RW, Tseng C (July 2002). "Identification of active antiviral compounds against a New York isolate of West Nile virus". Antiviral Research. 55 (1): 107–16. doi:10.1016/s0166-3542(02)00013-x. PMID 12076755.
- ^ McDonald CJ (1981). "The uses of systemic chemotherapeutic agents in psoriasis". Pharmacology & Therapeutics. 14 (1): 1–24. doi:10.1016/0163-7258(81)90008-5. PMID 7033998.
- ^ Shupack JL, Grieco AJ, Epstein AM, Sansaricq C, Snyderman SE (September 1977). "Azaribine, homocystinemia, and thrombosis". Archives of Dermatology. 113 (9): 1301–2. doi:10.1001/archderm.1977.01640090149047. PMID 578401.
- ^ Fung M, Thornton A, Mybeck K, Wu JH, Hornbuckle K, Muniz E (January 2001). "Evaluation of the characteristics of safety withdrawal of prescription drugs from worldwide pharmaceutical markets-1960 to 1999". Drug Information Journal. 35 (1): 293–317. doi:10.1177/009286150103500134.
- ^ Park JG, Ávila-Pérez G, Nogales A, Blanco-Lobo P, de la Torre JC, Martínez-Sobrido L (January 2020). "Identification and characterization of novel compounds with broad spectrum antiviral activity against influenza A and B viruses". Journal of Virology. doi:10.1128/JVI.02149-19. PMID 31941776.