Lille Model
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The Lille Model is a medical tool for predicting mortality in patients with alcoholic hepatitis who are not responding to steroid therapy. The model risk stratifies patients who have been receiving steroid treatment for seven days to predict who will improve and who should be considered for alternative treatment options including early referral for transplant.
The model is based on:
- Age
- Albumin
- Bilirubin (initial)
- Bilirubin (day 7)
- Creatinine
- PT
Initial model was based on a study of 238 patients and published in the Journal of Hepatology in 2003.[1] Recent cohort studies demonstrate that those with a Lille score above 0.45 are likely non-responders to steroid therapy.[2]
References
- ^ Mathurin, P; Abdelnour, M; Ramond, MJ; Carbonell, N; Fartoux, L; Serfaty, L; Valla, D; Poupon, R; Chaput, JC; Naveau, S (December 2003). "Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone". Hepatology. 38 (6): 1363–9. doi:10.1016/j.hep.2003.09.038. PMID 14647046.
- ^ Louvet, A; Naveau, S; Abdelnour, M; Ramond, MJ; Diaz, E; Fartoux, L; Dharancy, S; Texier, F; Hollebecque, A; Serfaty, L; Boleslawski, E; Deltenre, P; Canva, V; Pruvot, FR; Mathurin, P (June 2007). "The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids". Hepatology. 45 (6): 1348–54. doi:10.1002/hep.21607. PMID 17518367.