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Erin Calipari

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Erin Calipari
Alma materWhite Station High School
University of Massachusetts Amherst
Scientific career
InstitutionsVanderbilt University
Wake Forest University
Icahn School of Medicine at Mount Sinai
WebsiteCalipari Lab

Erin S. Calipari is an Assistant Professor of Pharmacology at the Vanderbilt University Brain Institute. She looks to understand the brain circuitry that is used for adaptive and maladaptive processes in reward, associative learning and motivation.

Early life and education

Calipari is the oldest daughter of John Calipari, an American basketball coach, and Ellen Calipari.[1] Calpiari took part in athletics whilst attending White Station High School. She played softball, basketball and hockey. She was part of the first generation in her family to attend to become an academic.[2] Calipari attended University of Massachusetts Amherst, where she studied biology and played for the UMass Minutewomen.[3] Calpari was a graduate student at Wake Forest University, where she earned a doctorate in neuropharmacology under the supervision of Sara Jones.[4] She used analytical chemistry and operant behaviour studies to understand how dopamine kinetics are impact by drug self-administration.[2] Calipari was a postdoctoral research associate in a genetics laboratory at the Icahn School of Medicine at Mount Sinai.[5][6] She focussed on how to understand neural circuit activity and transcriptional programs.[2]

Research and career

Calipari joined Vanderbilt University in 2017.[7] She works on the brain circuitry that is used for adaptive and maladaptive neurological processes including reward, associative learning and motivation, and how these are associated with psychiatric disease.[5][8][9] In Tennessee, where Calipari grew up, there are more prescriptions for opioids than there are people living in the state.[5] Calipari believes that drug addiction is a decision-making disease: people make decisions to choose to invest in drugs over other expenses. She looks at which parts of the brain are involved with making decisions, and how to reprogram them to make other choices.[5] Her lab use fibre photometry calcium imaging, which monitors neural activity in subpopulations of neurons using an optical fibers, optogenetics, and fast-scan cyclic voltammetry.[10] She is interested in why women are vulnerable to drug addiction, and how the immune system could be used to fight the opioid epidemic.[11][12] She believes that through the platform of sport it is possible to communicate the dangers of drug addiction.[13][14]

Whilst women are more susceptible to drug addiction, the majority of addiction studies are focussed on men.[15] This means that medication development has focussed on correcting addiction in men, and may explain why women do not respond to treatment in the same way as men.[15] Calipari found that when hormones related to fertility are high, women make stronger associations to clues in their environment and more likely to seek rewards, which makes them more prone to drug addiction and relapse.[5][15][16] Her research can be used by treatment centres to educate women about their decision making mechanisms.[15]

Selected publications

  • López AJ, Siciliano CA, Calipari ES. Activity-Dependent Epigenetic Remodeling in Cocaine Use Disorder. Handb Exp Pharmacol. 2019;10.1007/164_2019_257. doi:10.1007/164_2019_257[17]
  • Brady LJ, Hofford RS, Tat J, Calipari ES, Kiraly DD. Granulocyte-Colony Stimulating Factor Alters the Pharmacodynamic Properties of Cocaine in Female Mice. ACS Chem Neurosci. 2019;10(10):4213–4220. doi:10.1021/acschemneuro.9b00309[17]
  • Fakira AK, Peck EG, Liu Y, et al. The role of the neuropeptide PEN receptor, GPR83, in the reward pathway: Relationship to sex-differences. Neuropharmacology. 2019;157:107666. doi:10.1016/j.neuropharm.2019.107666[17]
  • Zhang H, Chaudhury D, Nectow AR, et al. α1- and β3-Adrenergic Receptor-Mediated Mesolimbic Homeostatic Plasticity Confers Resilience to Social Stress in Susceptible Mice. Biol Psychiatry. 2019;85(3):226–236. doi:10.1016/j.biopsych.2018.08.020[17]

Personal life

Calpari is married to Cody Siciliano, a neuroscientist at Vanderbilt University.[citation needed]

References

  1. ^ Dwyer, Danielle (April 4, 2015). "Erin Calipari, John's Daughter: 5 Fast Facts You Need to Know". Heavy.com. Retrieved July 27, 2019.
  2. ^ a b c Lindsley, Craig W. (June 19, 2019). "NeuroChat with Professor Erin Calipari". ACS Chemical Neuroscience. 10 (6): 2623–2624. doi:10.1021/acschemneuro.9b00181.
  3. ^ "2019-20 Women's Basketball Roster". University of Massachusetts Athletics. Retrieved July 27, 2019.
  4. ^ "Calipari Defended Dissertation on 9/30 – Congrats! | Neuroscience PhD at Wake Forest University - News Archive". neuroscience.graduate.wfu.edu. Retrieved July 27, 2019.
  5. ^ a b c d e "Meet the Calipari who holds court at Vanderbilt lab". The Tennessean. Retrieved July 27, 2019.
  6. ^ "Neuroscience Department - Nestler's Team". neuroscience.mssm.edu. Retrieved July 27, 2019.
  7. ^ MacMillan, Leigh. "New faculty: Erin Calipari, assistant professor of pharmacology". Vanderbilt University. Retrieved July 27, 2019.
  8. ^ Vanderbilt University (January 16, 2019), Erin Calipari Full Interview, retrieved July 27, 2019
  9. ^ "Vanderbilt University School of Medicine". wag.app.vanderbilt.edu. Retrieved July 27, 2019.
  10. ^ "Techniques". Calipari Lab. Retrieved July 27, 2019.
  11. ^ Callahan, Carolyn (February 7, 2019). "Coach Cal's oldest daughter uses unique position to reach, educate in battle against opioid epidemic". WLKY. Retrieved July 27, 2019.
  12. ^ "Your Immune System Could Aid Fight Against Opioid Addiction". from Technology Networks. Retrieved July 27, 2019.
  13. ^ "Q&A With Erin Calipari". UKNow. March 7, 2019. Retrieved July 27, 2019.
  14. ^ Communications, Vanderbilt Division of. "The Tennessean: Meet the Calipari who holds court at Vanderbilt lab". Vanderbilt University. Retrieved July 27, 2019.
  15. ^ a b c d "Women's hormones play role in drug addiction, higher relapse rates: Attention drawn to lack of female-specific research". ScienceDaily. Retrieved July 27, 2019.
  16. ^ Johnson, Amy R.; Thibeault, Kimberly C.; Lopez, Alberto J.; Peck, Emily G.; Sands, L. Paul; Sanders, Christina M.; Kutlu, Munir Gunes; Calipari, Erin S. (January 23, 2019). "Cues play a critical role in estrous cycle-dependent enhancement of cocaine reinforcement". Neuropsychopharmacology. 44 (7): 1189–1197. doi:10.1038/s41386-019-0320-0. ISSN 0893-133X. PMC 6785030. PMID 30728447.
  17. ^ a b c d "erin calipari - Search Results". PubMed. Retrieved March 5, 2020.
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