SPE

SPE may refer to:

Science and technology

Spe (planet), also known as 14 Andromedae b
Serum protein electrophoresis
Solar particle event, in which protons emitted by the Sun become accelerated to very high energies
Solid phase extraction, a separation process used to isolate compounds from a mixture
Solid-phase epitaxy, a method for forming crystalline materials from amorphous precursors
The Sound Pattern of English, a 1968 book by Noam Chomsky and Morris Halle about the phonology of English and analysis of phonological processes
Stanford prison experiment, in psychology, an infamous study of prisoner and prison guard roles
Subgame perfect equilibrium, in game theory, a refinement of a Nash equilibrium used in dynamic games
Synchronous payload envelope, in telecommunications, related to synchronous optical networking

Synergistic Processing Element, part of the Cell microprocessor used in the PlayStation 3 video game console
Software performance engineering, in performance engineering
Signal-Processing Engine, for example in the PowerPC e500
Statistical post-editing, in post-editing for machine translation
SPE Single pair Ethernet, a new technology to link Ethernet devices

Sauber Petronas Engineering, the company which manufactured engines for the Sauber F1 Team from 1997–2005
Sigma Phi Epsilon, a fraternity for male college students in the United States
Societas Privata Europaea, a Europe-wide form of a limited company
Société de Prospection Electrique, the former name of Schlumberger Limited, the world's largest oilfield services corporation
Sony Pictures Entertainment, an American-based entertainment company owned by media corporation Sony
SPE (company), former name of the Belgian energy company EDF Luminus
Special Police Establishment, predecessor of Central Bureau of Investigation, India
Special purpose entity, a legal entity created to fill a narrow or temporary objective

Sales process engineering
Sion Panvel Expressway
Supervisory patent examiner, a patent examiner, usually a civil servant, working at a patent office
SPE Certified, a food quality assurance certification
Société Parisienne d'Édition, a French publisher