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Limbic system-associated membrane protein

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Limbic system-associated membrane protein (LAMP) 64- to 68-kDa heavily glycosylated protein found in neurons, specifically it is distributed in cortical and subcortical regions of the limbic system.[1] LAMP protein is expressed on the surface of somata and proximal dendrites of neurons where it integrates via glycosyl-phosphatidyl-inositol (GPI) anchor.[2] Despite the name, LAMP is not expressed only in the limbic-associated areas, but also less intensely in the midbrain and hindbrain regions.[2]

References

  1. ^ Pimenta, A. F.; Fischer, I.; Levitt, P. (1996-05-08). "cDNA cloning and structural analysis of the human limbic-system-associated membrane protein (LAMP)". Gene. 170 (2): 189–195. doi:10.1016/0378-1119(96)84698-1. ISSN 0378-1119. PMID 8666243.
  2. ^ a b Innos, Jürgen; Koido, Kati; Philips, Mari-Anne; Vasar, Eero (2013-03-26). "Limbic system associated membrane protein as a potential target for neuropsychiatric disorders". Frontiers in Pharmacology. 4: 32. doi:10.3389/fphar.2013.00032. ISSN 1663-9812. PMC 3607788. PMID 23532449.{{cite journal}}: CS1 maint: unflagged free DOI (link)
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