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Heavy meromyosin

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Heavy meromyosin (HMM) is the larger of the two fragments obtained from the muscle protein myosin II following limited proteolysis by trypsin or chymotrypsin.[1] HMM contains two domains S-1 and S-2, S-1 contains is the globular head that can bind to actin while the S-2 domain projects at and angle from light meromyosin (LMM) connecting the two meromyosin fragments.

HMM is used to determine the polarity of actin filaments by decorating them with HMM then viewing them under the electron microscope.[2]

References

  1. ^ "Mechanism of the phosphorylation-dependent regulation of smooth muscle heavy meromyosin". PMID 2933403. {{cite journal}}: Cite journal requires |journal= (help)
  2. ^ "Evidence for biased bidirectional polymerization of actin filaments using heavy meromyosin prepared by an improved method". doi:10.1083/jcb.67.1.231. PMC 2109590. {{cite journal}}: Cite journal requires |journal= (help)


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