Cyanopeptolin
Cyanopeptolins are a class of oligopeptides produced by Microcystis and Planktothrix algae strains, and can be neurotoxic.[1][2][3] The production of cyanopeptolins occurs through nonribosomal peptides synthases (NRPS).[4]
Characteristics
Increased water temperatures, because of climate change and eutrophication of inland waters promote blooms of cyanobacteria, potentially threaten water contamination by the production of the toxic cyanopeptolin (CP1020).[1]
Exposure
Cyanopeptolin (CP1020) exposure in zebrafish affected pathways related to DNA damage, the circadian rhythm and response to light.[1]
See also
References
- ^ a b c "Molecular effects of the cyanobacterial toxin cyanopeptolin (CP1020) occurring in algal blooms: Global transcriptome analysis in zebrafish embryos" (PDF). Aquatic Toxicology. 149: 33–39. April 2014. doi:10.1016/j.aquatox.2014.01.018. PMID 24561424.
{{cite journal}}: Cite uses deprecated parameter|authors=(help) - ^ "Multiple Toxin Production in the Cyanobacterium Microcystis: Isolation of the Toxic Protease Inhibitor Cyanopeptolin 1020" (PDF). J. Nat. Prod. 73 (5): 980–984. 2010. doi:10.1021/np900818c. PMID 20405925.
{{cite journal}}: Cite uses deprecated parameter|authors=(help) - ^ "Cyanobacterial peptides – Nature's own combinatorial biosynthesis". FEMS Microbiology Reviews. 30 (4): 530–563. 2006. doi:10.1111/j.1574-6976.2006.00022.x. PMID 16774586.
{{cite journal}}: Cite uses deprecated parameter|authors=(help) - ^ "Limited Stability of Microcystins in Oligopeptide Compositions of Microcystis aeruginosa (Cyanobacteria): Implications in the Definition of Chemotypes". Toxins. 5 (6): 1089–1104. 2013. doi:10.3390/toxins5061089. PMC 3717771. PMID 23744054.
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