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Rubella virus 3′ cis-acting element

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Rubella virus 3′ cis-acting element
Predicted secondary structure and sequence conservation of Rubella_3
Identifiers
SymbolRubella_3
Alt. SymbolsRubella_cis_act
RfamRF00194
Other data
RNA typeCis-reg
Domain(s)Viruses
SOSO:0000233
PDB structuresPDBe

The Rubella virus 3′ cis-acting element RNA family represents a cis-acting element found at the 3′ UTR in the rubella virus. This family contains three conserved step loop structures.[1] Calreticulin (CAL), which is known to bind calcium in most eukaryotic cells, is able to specifically bind to the first stem loop of this RNA.[1] CAL binding is thought to be related to viral pathogenesis and in particular arthritis which occurs frequently in rubella infections in adults and is independent of viral viability. All stem loop structures are thought to be important for efficient viral replication and deletion of stem loop three is known to be lethal.[1]

See also

References

  1. ^ a b c Chen MH, Frey TK (April 1999). "Mutagenic analysis of the 3′ cis-acting elements of the rubella virus genome". Journal of Virology. 73 (4): 3386–3403. doi:10.1128/JVI.73.4.3386-3403.1999. PMC 104103. PMID 10074193.
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