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Benaroya Research Institute

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Coordinates: 47°36′36″N 122°19′44″W / 47.609885°N 122.328883°W / 47.609885; -122.328883
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Benaroya Research Institute
Benaroya Research Institute's glass fronted building at Virginia Mason
Established1956
Research typeBasic (non-clinical), Clinical and Translational Research
Field of research
Immune System and Autoimmune Disease Research
PresidentJane H. Buckner, MD[1]
Address1201 Ninth Avenue
LocationSeattle, WA
AffiliationsVirginia Mason Health System[2]
Websitewww.benaroyaresearch.org

Benaroya Research Institute (BRI) is a Seattle, Washington non-profit organization that conducts medical research on many diseases and immune disorders, including autoimmune disease. It is affiliated with Virginia Mason Health System, and is located on the campus of Virginia Mason Medical Center.[2]

Much of BRI's research aims to understand how immune cells function and why they malfunction to cause disease.[3][4] BRI researchers study how immune cells contribute to rheumatoid arthritis, type 1 diabetes, multiple sclerosis and other diseases.[3][4]

BRI uses translational research and clinical trials to carry its findings from the lab to the clinic, to inform how physicians diagnose and treat disease.[4][5]

History

BRI was founded in 1956 as the Virginia Mason Research Center."[6][7][8] In 1985, Gerald Nepom became BRI's director and established its immunology research program.[4][9][7]

In 1999, BRI moved into a new, 100,000 square-foot building at the corner of Seneca and 9th Avenue, in Seattle's First Hill neighborhood.[10] The building was named the Benaroya Research Institute in honor of donations from the Benaroya family.[11]

In the late 1990s, BRI's William Kwok and Nepom developed MHC class II tetramer technology that helps researchers find and study antigen-specific T cells.[12] These tetramers are customized (using different HLA/peptide combinations) for use by researchers to study how the immune system responds to many different diseases and pathogens, including influenza, human papillomavirus, allergies, type 1 diabetes, rheumatoid arthritis and multiple sclerosis.[12]

In 2016, Jane Buckner took over from Nepom and became BRI's president.[9][13]" Nepom remained at BRI as a researcher and faculty member.[9][13]

Research

BRI studies immune cells and immunotherapies that reprogram those cells; these therapies could inform treatments and cures for type 1 diabetes, multiple sclerosis, rheumatoid arthritis and other diseases.[4][14]

BRI's uses its biorepositories of blood and specimens from individuals with autoimmune diseases and other disorders, and from healthy individuals to conduct research.[15] BRI has eight biorepositories that contain samples dating back to the year 2000.[16]

In 2014, BRI was awarded a seven year, $27 million per-year grant to become headquarters of the Immune Tolerance Network (ITN), a clinical research consortium with more than 200 research sites around the world.[17] The ITN investigates how to retrain the immune system to tolerate organ transplants and reduce the effects of allergies, autoimmune diseases and other health issues.[17][18] The ITN is directed by Nepom.[17]

BRI's Carla Greenbaum is chair of Type 1 Diabetes TrialNet.[19] TrialNet is an international research network that is pursuing new ways to identify, slow the progression of and ultimately prevent type 1 diabetes.[20]

In 2016, BRI received a five-year, $8 million NIH grant to lead a collaboration that studies how the immune system responds to allergens in the lungs, and how those allergens trigger asthma attacks.[21] The collaboration includes researchers from BRI, UW Medicine and Seattle Children's Research Institute.[21] Their work could lead to new therapies for allergies and asthma.[22]

BRI is also studying immunotherapies to treat type 1 diabetes. In 2016, Buckner and her colleagues received $1 million from the Leona M. and Harry B. Helmsley Charitable Trust to investigate ways to change "attacker" cells into cells that stop disease.[23] The researchers are isolating the cells that mount autoimmune attacks, and then "reprogramming" them by editing their genes.[24][25]

In 2017, the Helmsley Trust awarded the researchers an additional $2 million to continue testing the edited cells in the lab.[25]

In 2017, BRI's Erik Wambre and his colleagues identified a type of cell, called Th2A, that appears to drive all allergies.[26] This discovery could change the trajectory of allergy research and treatment by informing to therapies that target this common enemy.[26][27] Th2A cells could also be used as biomarkers, or indicators to show whether a person has an allergy or is responding to therapy.[27][26]

In 2018, BRI's Emma L. Kuan and Steven F. Ziegler discovered that a protein called thymic stromal lymphopoietin (TSLP) helps breast cancer tumors survive and spread. They also showed that blocking this protein in laboratory models significantly inhibited the growth of breast cancer tumors and kept them from spreading. Kuan and Ziegler are investigating if drugs that block TSLP might be effective against breast cancer.[28][29]

In 2018, BRI researchers contributed to a finding about babies’ sleep patterns: Many infants sleep better and for longer when they start eating solid foods. In the study, half the babies subsisted entirely on breast milk until six months of age, while the other half started eating solid foods at three months of age. Compared to babies who were solely breast-fed, the infants who ate solid food slept for two more hours per week and woke up two fewer times per night. The findings were published in JAMA Pediatrics, and the study was led by Gideon Lack, a professor at King's College London whose work is funded by the Immune Tolerance Network – which is housed at BRI.[30][31]

In 2018, BRI's Bernard Khor was awarded an NIH grant to investigate why nearly 50 percent of people with Down syndrome (DS) have autoimmune diseases. Khor and BRI are building one of the world's first DS biorepositories to study why people with DS are so susceptible to autoimmune diseases. Dr. Khor's team will use these samples to analyze immune cells from patients with DS and patients with both DS and autoimmune disease. The researchers will compare their findings to samples from the patients’ healthy family members. This could lead to insights about autoimmune diseases and inform therapies to treat them.[32]

BRI's Peter Linsley contributed to research that helped James Allison and Tasuku Honjo win the Nobel Prize for Physiology and Medicine in December of 2018. Allison and Honjo received the prize for research related to checkpoint inhibitor therapies for cancer. Linsley is BRI's Director of Systems Immunology, and his research on T cell activation in the early 1990s significantly contributed to the body of knowledge that later helped Allison and Honjo pioneer this breakthrough approach.[33]  

In March 2019, Margaret McCormick, PhD, became BRI’s Executive Director after their previous director, Homer Lane, retired.[34]

In June 2019, BRI and Type 1 Diabetes TrialNet showed that an immunotherapy drug called teplizumab delayed T1D for a median of two years for those at high risk for the disease.[35]This is the first time scientists have been able to use a therapy to delay type 1 diabetes.[36]

BRI started conducting cancer research in 2014, in part to investigate why cancer patients developed autoimmunity as a side effect of taking checkpoint inhibitor immunotherapy.[37] In 2019, BRI received two grants to learn more about this cancer-autoimmunity connection. In May 2019, they received a grant from the Parker Institute for Cancer Immunotherapy, JDRF, and The Leona M. and Harry B. Helmsley Charitable Trust to study why some checkpoint inhibitor patients develop an autoimmune response that resembles type 1 diabetes.[38] In September 2019, BRI received a $4.5 million grant from the National Cancer Institute to study why immunotherapy only works for some people, and why it triggers an autoimmune response in others.[39]

In December 2019, BRI launched the Sound Life Project, which aims to profile the healthy human immune system to lay the groundwork for better ways to diagnose, treat and prevent immune system diseases such as rheumatoid arthritis, type 1 diabetes and multiple sclerosis. Scientists will examine the immune systems of healthy volunteers in two age segments (25-35 and 55-65) over two years with the goal of understanding what constitutes a “normal” baseline of young and aging immune systems, as well as other lifestyle and environmental factors that may influence it. The Sound Life Project is BRI’s initial project of a research collaboration led by the new Allen Institute for Immunology. BRI’s role is to provide detailed information about healthy immune systems to serve as a foundation for existing and future disease research programs.[40]

Funding and growth

BRI has received United States federal grants for research for a wide variety of research projects, including research on autoimmune diseases,[41] allergies[42] and asthma.[22]

In 2010, BRI became the main beneficiary of the annual Boeing Classic golf tournament.[43] The Boeing Classic has raised more than $6 million from 2005 to 2017 for BRI and other charities.[44]

In 2015, BRI ranked third in National Institutes of Health funding among Washington State research institutions.[45]

In 2016, BRI's annual budget was approximately $70 million.[46] Approximately 71 percent of BRI's 2016 research was supported by government research grants and contracts. The remaining revenues came from philanthropic donations, pharmaceutical studies, foundation grants and other sources.

References

  1. ^ Seattle Times Staff (1 February 2016). "Casa Latina selects Marcos Martinez as executive director". The Seattle Times. Retrieved 11 May 2016.
  2. ^ a b Smith, Rob (2016-01-06). "Marriage of Virginia Mason, Yakima Memorial is official". Puget Sound Business Journal. Puget Sound Business Journal. Retrieved 2016-05-12.
  3. ^ a b Apfel, Amelia (December 2014). "Cancer Cure Inc". Seattle Business Magazine. Retrieved 29 July 2016.
  4. ^ a b c d e Apfel, Amelia (August 2015). "Why BRI is a Global Leader in Immune System Research". Seattle Magazine. Retrieved 29 July 2016.
  5. ^ Allison, Karmel (2 September 2010). "On the Trail of Autoimmunity: Dr. Jane Buckner". A Sweet Life: The Diabetes Magazine. Retrieved 1 August 2016.
  6. ^ "Longtime Benaroya Research Institute Boss to Step Down". Puget Sound Business Journal. 22 July 2015. Retrieved 4 August 2016.
  7. ^ a b Reedy, Justin (22 May 2008). "UW Medicine Honors Outstanding Alumni". UW Today. Retrieved 4 August 2016.
  8. ^ "Washington Life Science History". washingtonlifescience.com. Info Resource Inc. Retrieved 4 August 2016.
  9. ^ a b c Smith, Rob (22 June 2015). "Longtime Benaroya Research Institute boss to step down". Puget Sound Business Journal. Retrieved 16 August 2016.
  10. ^ Flynn, Mike (19 Sep 1999). "Triumph for Virginia Mason". Puget Sound Business Journal. Retrieved 23 September 2016.
  11. ^ Pemberton-Butler, Lisa (13 September 1997). "Virginia Mason Names Building For Diabetes-Study Benefactors". The Seattle Times. Retrieved 26 September 2016.
  12. ^ a b Nepom, Gerald (15 March 2012). "MHC Class II Tetramers". Journal of Immunology. 188 (6): 2477–2482. doi:10.4049/jimmunol.1102398. PMC 3297979. PMID 22389204. Retrieved 27 September 2016.
  13. ^ a b Fox, Maggie (4 March 2016). "Feeding kids peanuts prevents allergies long-term, study shows". Today.com. Retrieved 16 August 2016.
  14. ^ Apfel, Amelia (December 2014). "Cancer Cure Inc". No. December 2014. Seattle Business Magazine. Retrieved 22 August 2016.
  15. ^ Garnick, Carol (3 June 2016). "People in research: Dr. James Lord takes 17,000 steps toward a cure". Puget Sound Business Journal. Retrieved 23 September 2016.
  16. ^ "BioMed USA Directory of North American Biorepositories". biomedusa.org. BioMed USA. Archived from the original on 24 September 2016. Retrieved 23 September 2016.
  17. ^ a b c Bauman, Valerie (23 Jan 2014). "Benaroya Research Institute wins grant to lead international immune research effort". Puget Sound Business Journal. Retrieved 23 September 2016.
  18. ^ Thompson, Dennis (4 March 2016). "Supervised Exposure Therapy for Peanut Allergy Lasts, Study Finds". Health Day. Retrieved 23 September 2016.
  19. ^ Azevedo, Margarida (4 April 2016). "TrialNet Researchers Develop Type1 Diabetes Classification". Diabetes News Journal. Retrieved 23 September 2016.
  20. ^ "Earlier intervention for type 1 diabetes sought with new staging classification". Medical Xpress. 7 March 2016. Retrieved 23 September 2016.
  21. ^ a b McGrane, Clare (23 August 2016). "New solutions for allergies and asthma? Seattle collaboration lands $8M grant to research treatments". GeekWire. Retrieved 29 September 2016.
  22. ^ a b "EXCLUSIVE: Benaroya Research Institute receives $8M to research new asthma treatments". Puget Sound Business Journal. 23 August 2016. Retrieved 29 September 2016.
  23. ^ "Researchers Work Toward New Type 1 Diabetes Therapies For Patients Like Juliana | On the Pulse". On the Pulse. 2016-03-22. Retrieved 2018-03-20.
  24. ^ Garnick, Coral (20 December 2017). "Seattle Children's receives $2 million in search for Type 1 diabetes immunotherapy cure". Puget Sound Business Journal. Retrieved 2018-02-24.
  25. ^ a b Kurs, Lindsay (13 December 2017). "Immunotherapy, Gene Editing Advances Extend to Type 1 Diabetes". On the Pulse. Seattle Children's. Retrieved 2018-03-24.
  26. ^ a b c "Got allergies? Scientists may have finally pinpointed the cells that trigger reactions". Science | AAAS. 2017-08-02. Retrieved 2018-03-20.
  27. ^ a b Doughton, Sandi (2017-08-02). "Got allergies? Seattle discovery could improve treatment — and possibly lead to cure". The Seattle Times. Retrieved 2018-03-20.
  28. ^ "A Breast Cancer Breakthrough In Seattle". Kiro7.com. March 21, 2018. Retrieved March 6, 2018.
  29. ^ "New Strategy to Stop Breast Cancer". Virginia Mason. January 19, 2018. Retrieved January 3, 2020.
  30. ^ Davis, Nicola (July 9, 2018). "Feeding your baby solids early may help them sleep, study suggests". The Guardian. Retrieved March 6, 2019.
  31. ^ "Association of Early Introduction of Solids With Infant Sleep". JAMA Pediatrics. 172. August 6, 2018 – via Jama Network.
  32. ^ "Researching a Link Between Down Syndrome and Autoimmunity". King5. October 25, 2018. Retrieved January 3, 2020.
  33. ^ "Discovery of cancer therapy by inhibition of negative immune regulation" (PDF). The Nobel Prize. 2018. Retrieved March 6, 2019.
  34. ^ "Margaret McCormick: Executive Director at Benaroya Research Institute at Virginia Mason". www.bizjournals.com. Retrieved 2020-01-03.
  35. ^ Falcon, Melanie (November 2019). "Groundbreaking Immunotherapy Delays Diabetes". Retrieved January 3, 2020.
  36. ^ "Groundbreaking Immunotherapy Can Delay Onset of Diabetes for 2 Years". NBC 5 Dallas-Fort Worth. Retrieved 2020-01-03.
  37. ^ "Groundbreaking Immunotherapy Can Delay Onset of Diabetes for 2 Years". NBC 5 Dallas-Fort Worth. Retrieved 2020-01-03.
  38. ^ "Parker Institute for Cancer Immunotherapy, JDRF and the Helmsley Charitable Trust Form Cancer and Diabetes Research Initiative". Parker Institute for Cancer Immunotherapy. 2019-05-29. Retrieved 2020-01-03.
  39. ^ odoyle (2019-10-29). "Benaroya Research Institute Receives $4.5 Million Grant to Predict Which Cancer Patients will Benefit from Immunotherapy". Benaroya Research Institute. Retrieved 2020-01-03.
  40. ^ "Allen Institute launches new immunology division with $125M from its late founder". GeekWire. 2018-12-12. Retrieved 2020-01-03.
  41. ^ "Benaroya Research Institute gets $2.2M grant". bizjournals.com. Puget Sound Business Journal. 31 August 2010. Retrieved 15 September 2011.
  42. ^ "Benaroya Research Institute gets $5.3M grant to study allergies". bizjournals.com. Puget Sound Business Journal. 20 February 2008. Retrieved 15 September 2011.
  43. ^ "Boeing Classic golf event changes charity beneficiary" (PDF). Puget Sound Business Journal. January 2010.
  44. ^ Eng, Heidi; Luschei, Abby (September 2017). "A Look Back at the 2017 Boeing Classic". King5.com. Retrieved March 19, 2018.
  45. ^ Garnick, Carol (8 June 2016). "Exclusive: NIH fixes database error, and Washington state's research grant tally shrinks". Puget Sound Business Journal. Retrieved 22 September 2016.
  46. ^ "The 2017 Leaders in Health Care Awards: Achievement in Medical Research". Seattle Business Magazine. 2017-02-02. Retrieved 2020-01-03.

Official website

47°36′36″N 122°19′44″W / 47.609885°N 122.328883°W / 47.609885; -122.328883

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