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Tooth regeneration

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Tooth regeneration is a stem cell based regenerative medicine procedure in the field of tissue engineering and stem cell biology to replace damaged or lost teeth by regrowing them from autologous stem cells.[1]

As a source of the new bioengineered teeth, somatic stem cells are collected and reprogrammed to induced pluripotent stem cells which can be placed in the dental lamina directly or placed in a reabsorbable biopolymer[2] in the shape of the new tooth.[3]

History

Young et al.[4] first demonstrated in 2002 that teeth could be regenerated from cells.

See also

References

  1. ^ Keishi Otsu; Mika Kumakami-Sakano; Naoki Fujiwara; Kazuko Kikuchi; Laetitia Keller; Hervé Lesot; Hidemitsu Harada (February 4, 2014). "Stem cell sources for tooth regeneration: current status and future prospects". Frontiers in Physiology. 5: 36. doi:10.3389/fphys.2014.00036. PMC 3912331. PMID 24550845.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  2. ^ Biopolymer methods in tissue engineering
  3. ^ Hill, David J. (2012-05-10). "Toothless no more – Researchers using stem cells to grow new teeth". Singularity Hub. Retrieved June 16, 2014.
  4. ^ Young CS, Terada S, Vacanti JP, Honda M, Bartlett JD, Yelick PC (2002). "Tissue engineering of complex tooth structures on biodegradable polymer scaffolds". J Dent Res. 81 (10): 695–700. doi:10.1177/154405910208101008. PMID 12351668.


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