Adhesion molecule (immunoglobulin-like)
| Adhes-Ig_like | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 a reassessment of the madcam-1 structure and its role in integrin recognition. | |||||||||
| Identifiers | |||||||||
| Symbol | Adhes-Ig_like | ||||||||
| Pfam | PF09085 | ||||||||
| Pfam clan | CL0011 | ||||||||
| InterPro | IPR015169 | ||||||||
| SCOP2 | 1gsm / SCOPe / SUPFAM | ||||||||
| |||||||||
In molecular biology, the adhesin molecule (immunoglobulin-like) is a protein domain. This domain is found in mucosal vascular addressin cell adhesion molecule 1 proteins (MAdCAM-1). These are cell adhesion molecules expressed on the endothelium in mucosa that guide the specific homing of lymphocytes into mucosal tissues. MAdCAM-1 belongs to a subclass of the immunoglobulin superfamily (IgSF), the members of which are ligands for integrins.[1] The crystal structure of this domain has been reported; it adopts an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology.[1][2]
See also
References
- ^ a b Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH (June 1998). "The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition". Structure. 6 (6): 793–801. doi:10.1016/S0969-2126(98)00080-X. PMID 9655832.
- ^ Dando J, Wilkinson KW, Ortlepp S, King DJ, Brady RL (February 2002). "A reassessment of the MAdCAM-1 structure and its role in integrin recognition" (PDF). Acta Crystallogr. D. 58 (Pt 2): 233–41. doi:10.1107/S0907444901020522. PMID 11807247.