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RNase E 5′ UTR element

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RNase E 5′ UTR element
Predicted secondary structure and sequence conservation of rne5
Identifiers
Symbolrne5
RfamRF00040
Other data
RNA typeCis-reg
Domain(s)Bacteria
SOSO:0000204
PDB structuresPDBe

In molecular biology, the RNase E 5′ UTR element is a cis-acting element located in the 5′ UTR of ribonuclease (RNase) E messenger RNA (mRNA).

RNase E is a key regulatory enzyme in the pathway of mRNA degradation in Escherichia coli. It is able to auto-regulate the degradation of its own mRNA in response to changes in RNase E activity. This rne 5′ UTR element acts as a sensor of cellular RNase E concentration enabling tight regulation of RNase E concentration and synthesis.[1]

See also

References

  1. ^ Diwa A, Bricker AL, Jain C, Belasco JG (2000). "An evolutionarily conserved RNA stem–loop functions as a sensor that directs feedback regulation of RNase E gene expression". Genes Dev. 14 (10): 1249–1260. PMC 316614. PMID 10817759.
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