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Ruth Plummer

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Ruth Plummer
CitizenshipUnited Kingdom
Alma mater
Known forEarly stage clinical trials, Drug development
Awards
Scientific career
Fieldsmelanoma, clinical trials, drug development
Institutions

Ruth Plummer FMedSci is a Professor of Experimental Cancer Medicine at Newcastle University and an oncologist specialising in treating patients with melanoma. Based in Newcastle, she directs the Sir Bobby Robson Cancer Trials Research Centre, set up by the Sir Bobby Robson Foundation to run early-stage clinical trials.v Plummer and the Newcastle team won a 2010 Translational Cancer Research Prize from Cancer Research UK for work using rucaparib to treat ovarian cancer. .[1] Plummer was elected as a fellow of the UK's Academy of Medical Sciences in 2018.[2][3]

Education and career

Plummer studied pre-clinical medicine at the University of Cambridge and completed a PhD and her clinical studies at the University of Oxford.

She then moved back to Newcastle, working at the Northern Institute for Cancer Research at Newcastle University. She lists her research interests as DNA repair and the early trials of new drugs.[4]

Plummer is Professor of Experimental Cancer Medicine at the Northern Institute for Cancer Research,[4] Newcastle University and an honorary consultant medical oncologist in Newcastle Hospital NHS Foundation Trust. She is Director of the Sir Bobby Robson Cancer Trials Research Centre within the Northern Centre for Cancer Care, w a dedicated clinical trials unit within the regional cancer centre. .[5] Plummer also leads the Newcastle Experimental Cancer Medicine Centre and the CRUK Newcastle Cancer Centre.[6]

Scientific work

Plummer was the first clinician to write a prescription for the cancer drug Rucaparib, a PARP inhibitor in 2003.[7] She led early clinical trials testing a combination of rucaparib (AG014699) and temozolomide in patients with advanced solid tumours, discovering that it well tolerateds.[8] She has also led early-stage trials that determined the safety of the combination of rucaparib and the chemotherapy drug carboplatin for advanced solid tumours,[9] Following successful clinical trials,[10] Rucaparib was given accelerated approval in the US by the FDA in 2016[11] and received a conditional licence by the EU in 2018.[12][13][14]

She has also led studies bringing a new type of drug, ATR inhibitor, into the clinic through early-stage clinical trials.[15] ATR, which stands for Ataxia telangiectasia and Rad3 related, regulates how cells respond to stress and can help promote DNA repair.

She chairs the Cancer Research UK New Agents Committee[16] and the Scientific Advisory Board for Target Ovarian Cancer.[17] She is a member of Cancer Research UK’s Clinical Research Committee and the Medical Research Council’s Stratified Medicines Group.[4] She sits on the clinical advisory board for Karus Therapeutics,[18] and is a scientific advisor for CV6 Therapeutics.[19]

Awards and honours

Plummer was elected a fellow of the Academy of Medical Sciences in 2018 ."[3][2] The Academy cited that she “has a world-leading reputation in the design and delivery of early phase clinical trials. She has taken many new cancer drugs into the clinic to determine their optimal dose, which have then become standard treatments with proven patient benefit.”[3]

She won a Translational Cancer Research Prize from Cancer Research UK for this work in 2010 for her work on PARP inhibitor trials.[1]

References

  1. ^ a b "Translational Cancer Research Prize", Cancer Research UK
  2. ^ a b "New Fellows for 2018 announced", The Academy of Medical Sciences
  3. ^ a b c "Fellow - Professor Ruth Plummer FMedSci", The Academy of Medical Sciences
  4. ^ a b c "Professor Ruth Plummer", Northern Institute for Cancer Research
  5. ^ "Meet the cancer patient who says Sir Bobby Robson helped save her life", Chronicle Live
  6. ^ "Professor Ruth Plummer", Cancer Research UK
  7. ^ "Rucaparib: targeting DNA repair and a patient's perspective", Cancer Research UK
  8. ^ Calvert, H, Plummer, R (1 December 2008). "Phase I Study Of The Poly(ADP-Ribose) Polymerase Inhibitor, AG014699, In Combination With Temozolomide in Patients with Advanced Solid Tumors". Clin Cancer Res. 14 (23): 7917–7923. doi:10.1158/1078-0432.CCR-08-1223. PMC 2652879. PMID 19047122.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. ^ Plummer, R, Wilson, R (28 March 2017). "A phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumours". British Journal of Cancer. 116 (7): 884–892. doi:10.1038/bjc.2017.36. PMC 5379148. PMID 28222073.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  10. ^ Ledermann, J, Coleman, R (3 November 2017). "Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial". The Lancet. 390 (10106): 1949–1961. doi:10.1016/S0140-6736(17)32440-6. PMC 5901715. PMID 28916367.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  11. ^ "Development History and FDA Approval Process for Rubraca", Drugs.com
  12. ^ "Cancer drug invented by Newcastle University approved for use in Europe", ITV News 24 March 2018
  13. ^ "First PARP inhibitor licensed for ovarian treatment indication in the EU", The Pharma Letter 30 May 2018
  14. ^ "Rubraca", European Medicines Agency 30 May 2018
  15. ^ Middleton M, Plummer, R (2016). "Phase I trial of first-in-class ATR inhibitor VX-970 in combination with gemcitabine (Gem) in advanced solid tumors (NCT02157792) [abstract]". J Clin Oncol.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  16. ^ "News Agents Committee", Cancer Research UK
  17. ^ "New Chair for Target Ovarian Cancer's Scientific Advisory Board", Target Ovarian Cancer
  18. ^ "Professor Ruth Plummer", Karus Therapeutics
  19. ^ "Scientific Advisors - Ruth Plummer MD", CV6 Therapeutics
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