Yoshizumi Ishino

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Yoshizumi Ishino
石野 良純
Born1959
Kyoto Prefecture, Japan
NationalityJapanese
Alma materOsaka University
Known forCRISPR
AwardsAMED Award (2017)
Scientific career
FieldsMolecular biology
Biotechnology
InstitutionsKyushu University
University of Illinois at Urbana–Champaign

Yoshizumi Ishino (石野 良純, Ishino Yoshizumi) is a Japanese molecular biologist, known for his discovering the DNA sequence of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR).

Research contribution

Ishino has contributed to the development of enzymology and nucleic acids research in his life. In 1987, he discovered the DNA sequence of CRISPR,[1] which is a basis of a biotechnology known as CRISPR-Cas9 that effectively edits genes. The "iap" gene in gut microbe E. coli was sequenced by Ishino and his colleagues in 1987.[2] Yoshizumi Ishino was one of the first scientists to have detected CRISPRs in E. coli. [3] Research of DNA replication of Archaea began by Yoshi in 1990.[4]

Biography

Ishino was born in Kyoto Prefecture, Japan. He received his BS, MS and PhD in 1981, 1983 and 1986, respectively, from Osaka University.[5] From 1987 to 1989, he served as a post-doctoral fellow in Dieter Söll's laboratory at Yale University.[6]

In 2002, he became a professor at Kyushu University.[7][8] Since October 2013, he has been a member of the NASA Astrobiology Institute, University of Illinois at Urbana–Champaign.[9]

After the completion of Yoshizumi's PHD, he became senior research scientist at the Bioproducts Development Center of Takara Shuzo. Later in life, he joined BERI (Biomolecular Engineering Research Institute), in which he conducted research on nucleic acids-related enzymes.[8]

Recognition

References

  1. ^ Ishino Y, Shinagawa H, Makino K, Amemura M, Nakata A (1987). "Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product". J Bacteriol. 169 (12): 5429–33. doi:10.1128/jb.169.12.5429-5433.1987. PMC 213968. PMID 3316184.
  2. ^ "CRISPR Natural History in Bacteria". Quanta Magazine. Retrieved 2019-04-01.
  3. ^ Forterre, Patrick; Krupovic, Mart; Ishino, Yoshizumi (2018-04-01). "History of CRISPR-Cas from Encounter with a Mysterious Repeated Sequence to Genome Editing Technology". Journal of Bacteriology. 200 (7): e00580–17. doi:10.1128/JB.00580-17. ISSN 0021-9193. PMC 5847661. PMID 29358495.
  4. ^ "Dr. Yoshizumi Ishino - CRISPR | Feb 11, 2019". www.targethealth.com. Retrieved 2019-04-01.
  5. ^ Yoshizumi Ishino | astrobiology.illinois.edu Archived September 30, 2015, at the Wayback Machine
  6. ^ Bioresource, Yoshizumi IshinoKyushu University; D, Bioenvironmental Sciences 43 19 · Ph. "Yoshizumi Ishino - Ph D - Kyushu University, Fukuoka - Kyudai - Graduate School of Bioresource and Bioenvironmental Sciences". Researchgate.net. Retrieved 29 October 2018.{{cite web}}: CS1 maint: numeric names: authors list (link)
  7. ^ [1]
  8. ^ a b "Yoshizumi Ishino". astrobiology.illinois.edu. Retrieved 2018-12-02.
  9. ^ "九州大学-研究者情報 [石野 良純 (教授) 農学研究院 生命機能科学部門]". Hyoka.ofc.kyushu-u.ac.jp. Retrieved 29 October 2018.

Further reading

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