Active chromatin sequence

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An active chromatin sequence (ACS) is a region of DNA in a eukaryotic chromosome in which histone modifications such as acetylation lead to exposure of the DNA sequence thus allowing binding of transcription factors and transcription to take place. ACSs may occur in non-expressed gene regions which are assumed to be "poised" for transcription.

See also

Chromatin

References

  1. Sabo PJ, Humbert R, Hawrylycz M, et al. (March 2004). "Genome-wide identification of DNaseI hypersensitive sites using active chromatin sequence libraries". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4537–42. doi:10.1073/pnas.0400678101. PMC 384782. PMID 15070753.


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