Amikhelline

Amikhelline
Clinical data
ATC code	none;
Pharmacokinetic data
Metabolism	none
Identifiers
	IUPAC name 9-(2-diethylaminoethoxy)-4-hydroxy-7-methylpyrano[3,2-f][1]benzoxol-5-one;
CAS Number	4439-67-2 ;
PubChem CID	71198;
ChemSpider	64334 ;
UNII	BD9T227F6M;
ChEMBL	ChEMBL2104025;
CompTox Dashboard (EPA)	DTXSID20196151 ;
Chemical and physical data
Formula	C18H21NO5
Molar mass	331.363 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C/1c3c(O\C(=C\1)C)c(OCCN(CC)CC)c2occc2c3O;
	InChI InChI=1S/C18H21NO5/c1-4-19(5-2)7-9-23-18-16-12(6-8-22-16)15(21)14-13(20)10-11(3)24-17(14)18/h6,8,10,21H,4-5,7,9H2,1-3H3 ; Key:QZBPFSZZMYTRIA-UHFFFAOYSA-N ;
	(verify)

Amikhelline is an antimitotic drug.^[1] It acts as a DNA intercalator^[2] and inhibits DNA polymerase.^[3]

References

^ Turchini MF, Geneix A, Perissel B, Malet P, Turchini JP. Characterization of chromosomal aberrations induced in man by various antimitotic agents. (French). Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales. 1985;179(3):331-9. PMID 2417673
^ Rucheton M, Jeanteur P. Studies on amikhellin. I. Intercalative binding to double-stranded DNA. Biochimie. 1973;55(11):1415-20. PMID 4364376
^ Rucheton M, Jeanteur P. Studies on amikhellin. II.-Inhibition of dna-polymerase from murine sarcoma leukemia virus. Biochimie. 1976;58(6):689-95. PMID 60141

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