Angiomyofibroblastoma

Angiomyofibroblastoma is an uncommon benign mesenchymal tumor. It occurs almost in the vulvo-vaginal area of women, but can also be observed in men.

The gross features of AMFB are well-circumscribed. Usually, most tumors grow slowly, and patients do not feel pain. It also has low tendency for local recurrence.

Location

In women
- Female genital tract^[1]
- Vulva^[2]
- Posterior perivesical space^[3]
In men
- Spermatic cord^[4]

Pathology

Microscopical examination shows abundant thin-walled blood vessels with hypocellular and hypercellular areas.

Immunohistochemistry

Almost all tumor cells have immunoreactivity for both desmin and vimentin. It also express estrogen receptors and/or progesterone receptors, but staining for cytokeratin is negative.^[5]

Digital slides

JRC:14780

References

Template:Research help

^ Wang, J; Sheng, W; Tu, X; Shi, D; Zhu, X; Zhang, R (2000). "Clinicopathologic analysis of angiomyofibroblastoma of the female genital tract". Chinese medical journal. 113 (11): 1036–9. PMID 11776120.
^ Seo, J. W.; Lee, K. A.; Yoon, N. R.; Lee, J. W.; Kim, B. G.; Bae, D. S. (2013). "Angiomyofibroblastoma of the vulva". Obstetrics & Gynecology Science. 56 (5): 349–51. doi:10.5468/ogs.2013.56.5.349. PMC 3784123. PMID 24328028.
^ Lim, K. J.; Moon, J. H.; Yoon, D. Y.; Cha, J. H.; Lee, I. J.; Min, S. J. (2008). "Angiomyofibroblastoma arising from the posterior perivesical space: A case report with MR findings". Korean Journal of Radiology. 9 (4): 382–5. doi:10.3348/kjr.2008.9.4.382. PMC 2627271. PMID 18682679.
^ Tzanakis, N. E.; Giannopoulos, G. A.; Efstathiou, S. P.; Rallis, G. E.; Nikiteas, N. I. (2010). "Angiomyofibroblastoma of the spermatic cord: A case report". Journal of Medical Case Reports. 4: 79. doi:10.1186/1752-1947-4-79. PMC 2838917. PMID 20202207.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Seo, J. W.; Lee, K. A.; Yoon, N. R.; Lee, J. W.; Kim, B. G.; Bae, D. S. (2013). "Angiomyofibroblastoma of the vulva". Obstetrics & Gynecology Science. 56 (5): 349–51. doi:10.5468/ogs.2013.56.5.349. PMC 3784123. PMID 24328028.

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[1] Wang, J; Sheng, W; Tu, X; Shi, D; Zhu, X; Zhang, R (2000). "Clinicopathologic analysis of angiomyofibroblastoma of the female genital tract". Chinese medical journal. 113 (11): 1036–9. PMID 11776120.

[2] Seo, J. W.; Lee, K. A.; Yoon, N. R.; Lee, J. W.; Kim, B. G.; Bae, D. S. (2013). "Angiomyofibroblastoma of the vulva". Obstetrics & Gynecology Science. 56 (5): 349–51. doi:10.5468/ogs.2013.56.5.349. PMC 3784123. PMID 24328028.

[3] Lim, K. J.; Moon, J. H.; Yoon, D. Y.; Cha, J. H.; Lee, I. J.; Min, S. J. (2008). "Angiomyofibroblastoma arising from the posterior perivesical space: A case report with MR findings". Korean Journal of Radiology. 9 (4): 382–5. doi:10.3348/kjr.2008.9.4.382. PMC 2627271. PMID 18682679.

[4] Tzanakis, N. E.; Giannopoulos, G. A.; Efstathiou, S. P.; Rallis, G. E.; Nikiteas, N. I. (2010). "Angiomyofibroblastoma of the spermatic cord: A case report". Journal of Medical Case Reports. 4: 79. doi:10.1186/1752-1947-4-79. PMC 2838917. PMID 20202207.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[5] Seo, J. W.; Lee, K. A.; Yoon, N. R.; Lee, J. W.; Kim, B. G.; Bae, D. S. (2013). "Angiomyofibroblastoma of the vulva". Obstetrics & Gynecology Science. 56 (5): 349–51. doi:10.5468/ogs.2013.56.5.349. PMC 3784123. PMID 24328028.

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