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Annihilation, in physics, is an effect that occurs when a particle collides with an antiparticle.
Annihilation may also refer to:
- Annihilation (album), 2001 Rebaelliun album
- Annihilation (comics), a Marvel Comics 2006 event featuring several cosmic characters.
- Annihilation: Conquest, a 2007 series featuring similar themes and marketed as a sequel of the above comic book series
- Annihilation (Athans novel), a 2004 Philip Athans novel
- Annihilation (VanderMeer novel), a 2014 novel by Jeff VanderMeer and the first entry in the Southern Reach Trilogy
- Annihilation (film), an upcoming film
- Human extinction, or Human annihilation, the end of civilization
- Mutual assured destruction
- Creation and annihilation operators
- A rule of classical logic
- Annihilationism, a minority Christian belief that the unsaved are destroyed rather than sent to Hell or Purgatory.
- "Annihilated", an episode from Law & Order: Special Victims Unit (season 8)
- "Annihilation", a song by Crucifix from Dehumanization, covered by Sepultura and A Perfect Circle
- Annihilation, a map pack for Call of Duty: Black Ops
- Annihilation, a legal intoxicant sold by Mary Joy
- Vaporization, instantaneous conversion of solid matter to a plasma or gas.
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