Antifungal protein

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PDB 1afp EBI.jpg
solution structure of the antifungal protein from aspergillus giganteus. evidence for disulphide configurational isomerism
Symbol Antifungal_prot
Pfam PF11402
InterPro IPR022706

In molecular biology, proteins in the antifungal protein family consist of five antiparallel beta strands which are highly twisted creating a beta barrel stabilised by four internal disulphide bridges.[1] A cationic site adjacent to a hydrophobic stretch on the protein surface may constitute a phospholipid binding site.[1]

Human epithelia produce antifungal proteins.[2] The proteins kill fungi by inducing apoptosis and/or forming pores on the cell membrane.[2]


  1. ^ a b Campos-Olivas R, Bruix M, Santoro J, Lacadena J, Martinez del Pozo A, Gavilanes JG, Rico M (March 1995). "NMR solution structure of the antifungal protein from Aspergillus giganteus: evidence for cysteine pairing isomerism". Biochemistry. 34 (9): 3009–21. doi:10.1021/bi00009a032. PMID 7893713. 
  2. ^ a b Hein, Kyaw Zaw; Takahashi, Hitoshi; Tsumori, Toshiko; Yasui, Yukihiko; Nanjoh, Yasuko; Toga, Tetsuo; Wu, Zhihong; Grötzinger, Joachim; Jung, Sascha (2015-10-20). "Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide". Proceedings of the National Academy of Sciences of the United States of America. 112 (42): 13039–13044. doi:10.1073/pnas.1511197112. ISSN 1091-6490. PMC 4620902Freely accessible. PMID 26438863. 

This article incorporates text from the public domain Pfam and InterPro IPR022706