Aspergillusol A
Appearance
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Names | |
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IUPAC name
[(2S,3R)-2,3-Dihydroxy-4-[(2Z)-2-hydroxyimino-3-(4-hydroxyphenyl)propanoyl]oxybutyl] (2Z)-2-hydroxyimino-3-(4-hydroxyphenyl)propanoate
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C22H24N2O10 | |
Molar mass | 476.438 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Aspergillusol A is an alpha-glucosidase inhibitor isolated from marine Aspergillus.[1] Structurally, it consists of an erythritol group in the center, with two hydroxyimino-phenylpropanoyl groups attached to it from either side. It was synthesized in 2010 by researchers from King Fahd University of Petroleum and Minerals, starting with 4-hydroxybenzaldehyde.[2]
References
- ^ Ingavat, N; Dobereiner, J; Wiyakrutta, S; Mahidol, C; Ruchirawat, S; Kittakoop, P (2009). "Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus". Journal of Natural Products. 72 (11): 2049–52. doi:10.1021/np9003883. PMID 19824618.
- ^ Ullah, N.; Haladu, S. A. (2010). "The first total synthesis of aspergillusol A, an alpha-glucosidase inhibitor". Natural Product Communications. 5 (7): 1077–1080. PMID 20734944.