BCYRN1

An Error has occurred retrieving Wikidata item for infobox

Brain cytoplasmic RNA 1 is a protein that in humans is encoded by the BCYRN1 gene.

Function

This gene, which encodes a neural small non-messenger RNA, is a member of the family of interspersed repetitive DNA, and its product represents an example of a primate tissue-specific RNA polymerase III transcript. The RNA sequence is divided into three domains: a 5' portion homologous to the Alu Lm, a central adenosine-rich region, and the terminal 43-nt nonrepetitive domain. It is believed that this gene was retropositionally generated and recruited into a function regulating dendritic protein biosynthesis. At least two pseudogenes of this gene have been identified.

Further reading

• Iacoangeli A, Lin Y, Morley EJ, Muslimov IA, Bianchi R, Reilly J, Weedon J, Diallo R, Böcker W, Tiedge H (2004). "BC200 RNA in invasive and preinvasive breast cancer". Carcinogenesis. 25 (11): 2125–33. doi:10.1093/carcin/bgh228. PMID 15240511.
• Kobayashi S, Higuchi T, Anzai K (2005). "Application of the BC1 RNA gene promoter for short hairpin RNA expression in cultured neuronal cells". Biochem. Biophys. Res. Commun. 334 (4): 1305–9. doi:10.1016/j.bbrc.2005.07.033. PMID 16054886.
• Mus E, Hof PR, Tiedge H (2007). "Dendritic BC200 RNA in aging and in Alzheimer's disease". Proc. Natl. Acad. Sci. U.S.A. 104 (25): 10679–84. doi:10.1073/pnas.0701532104. PMC 1965572. PMID 17553964.
• Bennett CL, Chen Y, Vignali M, Lo RS, Mason AG, Unal A, Huq Saifee NP, Fields S, La Spada AR (2013). "Protein interaction analysis of senataxin and the ALS4 L389S mutant yields insights into senataxin post-translational modification and uncovers mutant-specific binding with a brain cytoplasmic RNA-encoded peptide". PLoS ONE. 8 (11): e78837. doi:10.1371/journal.pone.0078837. PMC 3823977. PMID 24244371.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Booy EP, McRae EK, Howard R, Deo SR, Ariyo EO, Dzananovic E, Meier M, Stetefeld J, McKenna SA (2016). "RNA Helicase Associated with AU-rich Element (RHAU/DHX36) Interacts with the 3'-Tail of the Long Non-coding RNA BC200 (BCYRN1)". J. Biol. Chem. 291 (10): 5355–72. doi:10.1074/jbc.M115.711499. PMC 4777866. PMID 26740632.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Singh R, Gupta SC, Peng WX, Zhou N, Pochampally R, Atfi A, Watabe K, Lu Z, Mo YY (2016). "Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis". Cell Death Dis. 7 (6): e2262. doi:10.1038/cddis.2016.168. PMC 5143396. PMID 27277684.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.