BQ-123

BQ-123^[1]
Names
	IUPAC name 2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid
	Other names Cyclo(D-trp-D-asp-L-pro-D-val-L-leu)
Identifiers
CAS Number	136553-81-6 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL1269102 ;
IUPHAR/BPS	997;
PubChem CID	443289;
CompTox Dashboard (EPA)	DTXSID70929476 ;
	SMILES CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43;
Properties
Chemical formula	C31H42N6O7
Molar mass	610.712 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

BQ-123 is a cyclic peptide consisting of five amino acids. The amino acid sequence is D-tryptamine-D-aspartic acid-L-proline-D-valine-L-leucine.

BQ-123 is a selective ET_A endothelin receptor antagonist.^[1]^[2] As such, it is used as a biochemical tool in the study of endothelin receptor function.

References

^ ^a ^b BQ-123 at Sigma-Aldrich
^ Ishikawa, Kiyofumi; Fukami, Takehiro; Nagase, Toshio; Fujita, Kagari; Hayama, Takashi; Niiyama, Kenji; Mase, Toshiaki; Ihara, Masaki; Yano, Mitsuo (1992). "Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications". Journal of Medicinal Chemistry. 35 (11): 1239–42.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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[Sigma-1] BQ-123 at Sigma-Aldrich

[JAntibiot1987-Kino-2] Ishikawa, Kiyofumi; Fukami, Takehiro; Nagase, Toshio; Fujita, Kagari; Hayama, Takashi; Niiyama, Kenji; Mase, Toshiaki; Ihara, Masaki; Yano, Mitsuo (1992). "Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications". Journal of Medicinal Chemistry. 35 (11): 1239–42.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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[2]