Adiposogenital dystrophy

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Adiposogenital dystrophy
Synonyms Babinski-Fröhlich syndrome[1][2][3][4] (commonly associated with slipped capital femoral epiphysis),Froelich's syndrome, Frölich's Syndrome , Hypothalamic Infantilism-Obesity , Launois-Cleret Syndrome , Sexual Infantilism
Naked woman with lipomatous Frohlich's syndrome.jpg
Classification and external resources
Specialty endocrinology
ICD-10 E23.6
ICD-9-CM 253.8
DiseasesDB 29318

Adiposogenital dystrophy is a condition which may be caused by tertiary hypogonadism originating from decreased levels in GnRH. Low levels of GnRH has been associated with defects of the feeding centers of the hypothalamus[citation needed], leading to an increased consumption of food and thus caloric intake.


It is characterized by:

It is usually associated with tumors of the hypothalamus, causing increased appetite and depressed secretion of gonadotropin. It seems to affect males mostly.

Many overweight children may appear to have the disorder because of the concurrence of obesity and retarded sexual development; these children have no endocrine disturbances, however, and they mature normally after delayed puberty.




  1. ^ synd/1792 at Who Named It? - Babinski-Fröchlich syndrome
  2. ^ J. F. Babinski. Tumeur du corps pituitaire sans acromégalie et avec arrêt de développement des organes génitaux. Revue neurologique, Paris, 1900, 8: 531-535.
  3. ^ A. Fröhlich. Ein Fall von Tumor der Hypophysis cerebri ohne Akromegalie. Wiener klinische Rundschau, 1901, 15: 833-836; 906-908.
  4. ^ Zárate A, Saucedo R (2007). "[The adiposogenital distrophy or Frohlich syndrome and the beginning of the concept of neuroendocrinology]". Gac Med Mex (in Spanish). 143 (4): 349–50. PMID 17969845.