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People called Serapion:
- Serapion of Alexandria (3rd century BC), Greek physician
- Serapion, probably negotiated in 48 BC for Caesar with Achillas, strategos of Cyprus in 43 BC, executed in 41 BC
- Bar-Serapion, Syrian stoicist.
- Saint Serapion of Macedonia (d. 195), Martyr
- Serapion of Antioch (c. 200 AD), Patriarch of Antioch
- Serapion (Disciple of Plotinus) was a 3rd-century neoplatonic philosopher and student of Plotinus
- Saint Serapion of Thmuis (4th century)
- Yahya ibn Sarafyun (9th century), also known as Serapion the Elder or Johannes Serapion, Christian physician who wrote two medical compilations in Syriac
- Serapion the Younger (c. 12th century), physician who wrote The Book of Simple Medicine (in Arabic)
- Serapion of Vladimir (13th century), bishop of Vladimir
- Saint Serapion of Algiers (1179–1240), Mercedarian saint
- Saint Serapion (Archbishop of Novgorod) (d. 1516)
- Serapion of Egypt (1709-1903), Coptic monk
- Serapion (Coptic bishop of Los Angeles) (b. 1951)
- Sarapion (Serapion), ancient port city in present-day south-central Somalia
- Saint Serapion (Zurbarán), an oil on canvas painting by the Spanish artist Francisco Zurbarán.
- Serapion Brothers, a literary movement in the early Soviet Union
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