Bronidox

Bronidox
Names
	Preferred IUPAC name 5-Bromo-5-nitro-1,3-dioxane
	Other names 5-Bromo-5-nitro-m-dioxane
Identifiers
CAS Number	30007-47-7 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL3185787;
ChemSpider	1741 ;
ECHA InfoCard	100.045.441
EC Number	250-001-7;
PubChem CID	1807;
UNII	U184I9QBNM ;
CompTox Dashboard (EPA)	DTXSID1044560 ;
	InChI InChI=1S/C4H6BrNO4/c5-4(6(7)8)1-9-3-10-2-4/h1-3H2 Key: XVBRCOKDZVQYAY-UHFFFAOYSA-N ; InChI=1/C4H6BrNO4/c5-4(6(7)8)1-9-3-10-2-4/h1-3H2 Key: XVBRCOKDZVQYAY-UHFFFAOYAG;
	SMILES O=[N+]([O-])C1(Br)COCOC1;
Properties
Chemical formula	C4H6BrNO4
Molar mass	211.999 g·mol−1
Appearance	White crystalline powder
Melting point	60 °C (140 °F; 333 K); 58.5−62 °C
Solubility in water	insoluble
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Toxic
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H302, H314, H315, H317, H410
Precautionary statements	P260, P261, P264, P270, P272, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P332+P313, P333+P313, P362, P363, P391, P405, P501
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	590 mg/kg (mouse, oral); 455 mg/kg (rat, oral); 31 mg/kg (rat, ipr.); 2500 µg (mouse, skin); 2500 µg (rat, skin)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Bronidox, or 5-bromo-5-nitro-1,3-dioxane, is an antimicrobial chemical compound.

Bronidox causes inhibition of enzyme activity in bacteria.^[3]

Bronidox is corrosive to metals.^[4]

Uses

Bactericide
Fungicide, effective against yeast and other fungi^{[citation needed]}
It is used in immunology for preserving antibodies and antisera in 0.1 - 0.5% concentration. It is used as preservative to avoid use of sodium azide.
Stabilizer
Surfactant
Used in cosmetics since the mid-1970s as preservative for shampoos, foam bath, etc. Maximum concentration is 0.1%.
Some users do not recommend use in preparations destined for in vivo or tissue culture work^[5]

^ 5-BROMO-5-NITRO-1,3-DIOXANE Archived March 3, 2016, at the Wayback Machine, chemicalland21.com
^ "Archived copy" (PDF). Archived from the original (PDF) on September 29, 2007. Retrieved March 19, 2006.{{cite web}}: CS1 maint: archived copy as title (link)
^ Ghannoum M, Thomson M, Bowman W, Al-Khalil S (1986). "Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane (bronidox)". Folia Microbiol. (Praha). 31 (1): 19–31. doi:10.1007/BF02928676. PMID 3082729. S2CID 23920602.
^ http://www.products.cognis.com/COGNIS/prodleaf.nsf/(SBU_Catalog)/FFAD30C61B67EFEB41256B4100427DD1/$File/BRONIDOX_r_L_5_E.pdf ^{[dead link]}
^ [1] Archived December 21, 2004, at the Wayback Machine