Bruce H. Lipshutz
Bruce H. Lipshutz (born 1951) is an American chemist. He is a professor at the University of California, Santa Barbara.[1]
Biography
Lipshutz received his undergraduate degree in chemistry from Binghamton University in 1973. His graduate work was supervised by Harry H. Wasserman at Yale. After a PhD degree in 1977, he spent two years at Harvard as a post-doctoral researcher in the group of Nobel Laureate E. J. Corey. Soon after, he accepted a position of Assistant Professor at UCSB rising to the ranks of Professor in 1987. He has received the Alfred P. Sloan Foundation Fellowship and the Camille & Henry Dreyfus Teacher-Scholar Award. In 2011 he was awarded Presidential Green Chemistry Award.[2] He is Co-founder of Zymes LLC.[3]
Contributions
Reagents
- Aqueous Micellar Catalysis using TPGS-750-M[4] and Nok.[5]
- Sustainable Palladium catalysis.[6][7]
- 2-(Trimethylsilyl)ethoxymethyl chloride: hydroxyl protecting group, selectively cleaved with fluoride ion under mild conditions.[8]
- Di-(4-chlorobenzyl)azodicarboxylate (DCAD): recyclable and convenient alternative to diethyl azodicarboxylate (DEAD) or diisopropyl azodicarboxylate (DIAD) in Mitsunobu reaction.[9]
- Ligated copper hydride.[10][11]
- Heterogeneous catalysts: nickel-on-charcoal, copper-on-charcoal, nickel-in-graphite, copper+nickel-on-charcoal.
Methodologies
- Higher order organocuprates (Lipshutz cuprates).[12]
- Chiral and achiral conjugate reductions.
References
- ^ Department of Chemistry and Biochemistry, UCSB: People, Faculty
- ^ Past Award Entries and Recipients | Green Chemistry | US EPA
- ^ Zymes llc Archived July 17, 2008, at the Wayback Machine
- ^ TPGS-750-M: A Second-Generation Amphiphile for Metal-Catalyzed Cross-Couplings in Water at Room Temperature [1]
- ^ “Nok”: A Phytosterol-Based Amphiphile Enabling Transition-Metal-Catalyzed Couplings in Water at Room Temperature [2]
- ^ Sustainable Fe–ppm Pd nanoparticle catalysis of Suzuki-Miyaura cross-couplings in water [3]
- ^ HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-Catalyzed Cross-Couplings in Water at Room Temperature [4]
- ^ β-(Trimethylsilyl)ethoxymethyl chloride. A new reagent for the protection of the hydroxyl group [5]
- ^ Simplification of the Mitsunobu Reaction. Di-p-chlorobenzyl Azodicarboxylate: A New Azodicarboxylate [6]
- ^ (BDP)CuH: A "Hot" Stryker's reagent for Use in Achiral Conjugate Reductions [7]
- ^ Asymmetric Hydrosilylation of Aryl Ketones Catalyzed by Copper Hydride Complexed by Nonracemic Biphenyl Bis-phosphine Ligands [8]
- ^ Bruce H. Lipshutz, Robert Moretti, Robert Crow "Mixed Higher-order Cyanocuprate-induced Epoxide Openings: 1-Benzyloxy-4-penten-2-ol" Org. Synth. 1990, volume 69, pp. 80. {{DOI:10.15227/orgsyn.069.0080}}
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