Bufalin
Bufalin, is a cardiotonic steroid originally isolated from the Chinese toad venom. It is a component found in many chinese traditional medicine.[1]
Usage
Researches showed that Bufalin has an antitumor effect against various malignancies, such as: hepatocellular [2] and lung carcinoma [3] However, as with other bufadienolides, its use is hampered by its cardiotoxicity.[4]
Notes and references
- ^ "Datasheet: Bufotalin sc-sc-200136" Santa Cruz Biotechnology, Inc.http://datasheets.scbt.com/sc-200136.pdf
- ^ Zhang ZJ (Feb 2014). "Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice". J Transl Med. 12: 57. doi:10.1186/1479-5876-12-57. PMC 4015709. PMID 24581171.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Wu SH (2014). "Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways". Am J Chin Med. 42 (3): 729–42. doi:10.1142/S0192415X14500475. PMID 24871662.
- ^ Ma H (Jul 2012). "The novel antidote Bezoar Bovis prevents the cardiotoxicity of Toad (Bufo bufo gargarizans Canto) Venom in mice". Exp Toxicol Pathol. 64 (5): 417–23. doi:10.1016/j.etp.2010.10.007. PMID 21084181.