Bufalin

Bufalin
Names
	IUPAC name (3β,5β)-3,14-Dihydroxybufa-20,22-dienolide
Identifiers
CAS Number	465-21-4;
3D model (JSmol)	Interactive image;
ChemSpider	7826155;
ECHA InfoCard	100.150.073
CompTox Dashboard (EPA)	DTXSID90873563 ;
	InChI InChI=1S/C24H34O4/c1-22-10-7-17(25)13-16(22)4-5-20-19(22)8-11-23(2)18(9-12-24(20,23)27)15-3-6-21(26)28-14-15/h3,6,14,16-20,25,27H,4-5,7-13H2,1-2H3/t16-,17+,18-,19+,20-,22+,23-,24+/m1/s1 Key: QEEBRPGZBVVINN-BMPKRDENSA-N;
	SMILES C[C@]12CC[C@@H](C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@@]3(CC[C@@H]4c5ccc(=O)oc5)O)C)O;
Properties
Chemical formula	C24H34O4
Molar mass	386.532 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Bufalin, is a cardiotonic steroid originally isolated from the Chinese toad venom. It is a component found in many chinese traditional medicine.^[1]

Usage

Bufalin has a in vitro antitumor effects against various malignancies, includiing hepatocellular^[2] and lung carcinoma.^[3] However, as with other bufadienolides, its use is hampered by its cardiotoxicity.^[4]

References

^ "Datasheet: Bufotalin sc-sc-200136" Santa Cruz Biotechnology, Inc.https://datasheets.scbt.com/sc-200136.pdf
^ Zhang ZJ (Feb 2014). "Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice". J Transl Med. 12: 57. doi:10.1186/1479-5876-12-57. PMC 4015709. PMID 24581171.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Wu SH (2014). "Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways". Am J Chin Med. 42 (3): 729–42. doi:10.1142/S0192415X14500475. PMID 24871662.
^ Ma H (Jul 2012). "The novel antidote Bezoar Bovis prevents the cardiotoxicity of Toad (Bufo bufo gargarizans Canto) Venom in mice". Exp Toxicol Pathol. 64 (5): 417–23. doi:10.1016/j.etp.2010.10.007. PMID 21084181.

[santacruz-1] "Datasheet: Bufotalin sc-sc-200136" Santa Cruz Biotechnology, Inc.https://datasheets.scbt.com/sc-200136.pdf

[pmid_=_24581171-2] Zhang ZJ (Feb 2014). "Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice". J Transl Med. 12: 57. doi:10.1186/1479-5876-12-57. PMC 4015709. PMID 24581171.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid_=_24871662-3] Wu SH (2014). "Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways". Am J Chin Med. 42 (3): 729–42. doi:10.1142/S0192415X14500475. PMID 24871662.

[pmid_=_21084181-4] Ma H (Jul 2012). "The novel antidote Bezoar Bovis prevents the cardiotoxicity of Toad (Bufo bufo gargarizans Canto) Venom in mice". Exp Toxicol Pathol. 64 (5): 417–23. doi:10.1016/j.etp.2010.10.007. PMID 21084181.

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