BZIP intron ascomycota

The bZIP intron ascomycota is an unconventional bZIP intron found in some of the Ascomycota fungi, mainly in filamentous fungi from Pezizomycotina subphylum.^[1] The structure consists of two hairpins: a longer on at the 5′ and a shorter one at the 3’. Loop regions of the hairpins define the position of splice sites recognised by endoribonuclease Ire1 in response to ER stress. The unconventional splicing in this group results in excising introns of typical length 20 or 23 nt and it was first described in Trichoderma reesei and Aspergillus nidulans hacA mRNAs.^[2]

References

^ Hooks KB, Griffiths-Jones S (2011). "Conserved RNA structures in the non-canonical Hac1/Xbp1 intron". RNA Biol. 8 (4): 552–556. doi:10.4161/rna.8.4.15396. PMC 3225973. PMID 21593604.
^ Saloheimo M, Valkonen M, Penttila M (2003). "Activation mechanisms of the HAC1-mediated unfolded protein response in filamentous fungi". Mol Microbiol. 47 (4): 1149–1161. doi:10.1046/j.1365-2958.2003.03363.x. PMID 12581366.

[Hooks-1] Hooks KB, Griffiths-Jones S (2011). "Conserved RNA structures in the non-canonical Hac1/Xbp1 intron". RNA Biol. 8 (4): 552–556. doi:10.4161/rna.8.4.15396. PMC 3225973. PMID 21593604.

[2] Saloheimo M, Valkonen M, Penttila M (2003). "Activation mechanisms of the HAC1-mediated unfolded protein response in filamentous fungi". Mol Microbiol. 47 (4): 1149–1161. doi:10.1046/j.1365-2958.2003.03363.x. PMID 12581366.

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