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Calamine

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This article is about the medication. For other uses, see Calamine (disambiguation).
Calamine
A puddle of a thin pink lotion, next to a pink plastic bottle
Calamine lotion and container
Combination of
zinc oxideastringent
ferric oxideantipruritic
Clinical data
PronunciationKAL a mine[1]
ATC code

Calamine, also known as calamine lotion, is a medication used to treat mild itchiness.[2][3] This includes from sunburn, insect bites, poison oak, or other mild skin conditions.[4][5] It may also help dry out skin irritation.[1] It is applied on the skin as a cream or lotion.[2]

Side effects may include skin irritation.[4] It is considered to be safe in pregnancy.[4] Calamine is a combination of zinc oxide and 0.5% ferric oxide (Fe2O3).[6] The lotion is produced with additional ingredients like phenol and calcium hydroxide.[6][7]

Calamine lotion has been used as far back as 1500 BC.[8] It is on the World Health Organization's List of Essential Medicines for being one of the most effective and safe medicines needed in a health system.[9] Calamine is available over the counter as a generic medication.[5] The wholesale cost in the developing world is about USD$0.25–3.85 per 100 mL bottle.[10] In the United Kingdom, it costs the National Health Service about £0.44.[2]

Medical uses

Calamine is used to treat itchiness.[2] This includes from sunburn, insect bite, or other mild skin conditions.[4][5]

Formulation

Calamine is mixed with either zinc oxide (ZnO) with about 0.5% ferric oxide (Fe2O3)[11][12] or a zinc carbonate compound.[13][14]

Calamine lotion is a component of the zinc-impregnated gauze wrap used to treat ulcers of the leg in Unna boots.

FDA

In a 1992 press release, the U.S. Food and Drug Administration announced that no proof had been submitted showing calamine to be safe for use or effective in treating bug bites, stings, and rashes from poison ivy, poison oak, and poison sumac.[15]

In a September 2, 2008 document, the U.S. Food and Drug Administration recommended applying topical OTC skin protectants, such as calamine, to relieve the itch caused by poisonous plants such as poison ivy, poison oak, and poison sumac.[16]

References

  1. ^ a b "Calamine (topical) medical facts from Drugs.com". www.drugs.com. Archived from the original on 2017-11-05. {{cite web}}: |archive-date= / |archive-url= timestamp mismatch; 2013-16-08 suggested (help); Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  2. ^ a b c d British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 801. ISBN 9780857111562.
  3. ^ WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 303. ISBN 9789241547659. Archived from the original (PDF) on 13 December 2016. Retrieved 8 December 2016. {{cite book}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  4. ^ a b c d "Aqueous Calamine Cream BP - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. 18 November 2016. Archived from the original on 30 December 2016. Retrieved 29 December 2016. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  5. ^ a b c Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 191. ISBN 9781284057560.
  6. ^ a b Braun-Falco, Otto; Plewig, Gerd; Wolff, Helmut Heinrich; Burgdorf, Walter (2012). Dermatology (2 ed.). Springer Science & Business Media. p. 1724. ISBN 9783642979316. Archived from the original on 2016-12-29. {{cite book}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  7. ^ Ma, Joseph K. H.; Hadzija, Boka (2012). Basic Physical Pharmacy. Jones & Bartlett Publishers. p. 327. ISBN 9780763757342. Archived from the original on 2016-12-30. {{cite book}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  8. ^ Bendich, Adrianne; Deckelbaum, Richard J. (2016). Preventive Nutrition: The Comprehensive Guide for Health Professionals (5 ed.). Springer. p. 608. ISBN 9783319224312. Archived from the original on 2016-12-30. {{cite book}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  9. ^ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived from the original (PDF) on 13 December 2016. Retrieved 8 December 2016. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  10. ^ "Calamine". International Drug Price Indicator Guide. Retrieved 8 December 2016.
  11. ^ Calvert, James. "Zinc and Cadmium". Physics. Archived from the original on 29 January 2013. Retrieved 21 January 2013. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  12. ^ ScienceLab.com, Inc. "Calamine, Powder, USP". Alphabetical Listing of Chemicals. ScienceLab.com, Inc. Archived from the original on 10 February 2013. Retrieved 21 January 2013. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  13. ^ Martin (ed), Elizabeth A. (2012). Concise Medical Dictionary. Oxford: Oxford University Press. pp. "calamine". ISBN 9780191727016. Archived from the original on 2014-03-13. {{cite book}}: |last= has generic name (help); Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  14. ^ Richards, Alan W. "Zinc processing". Encyclopædia Britannica. Encyclopædia Britannica, Inc. Archived from the original on 12 March 2014. Retrieved 12 March 2014. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  15. ^ "Banning 415 Ingredients from Seven Categories of NonPrescription Drugs". Press Release. FDA. P92-27. Archived from the original on 13 May 2009.
  16. ^ September 2, 2008 FDA Document Archived July 16, 2010, at the Wayback Machine
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