Carcinoma ex pleomorphic adenoma
|Carcinoma ex pleomorphic adenoma|
|Micrograph of a carcinoma ex pleomorphic adenoma. The carcinoma component is on the lower right of the image. Benign parotid gland is seen at the left and pleomorphic adenoma is seen at the upper right. H&E stain.|
Its prognosis depends on the stage. Early tumours have essentially a benign behaviour.
Signs and symptoms
The signs and symptoms are similar to other malignant salivary gland tumours; however, it may have been preceded by an appreciable mass that was long-standing and did not appear to be growing.
Carcinoma ex pleomorphic adenoma is diagnosed by examining it under the microscope with consideration of the individual history.
In approximately 75% of cases ca ex PAs arise in a pleomorphic adenoma that is apparent when the tumour is excised. In the other approximately 25% of cases the individual had a pleomorphic adenoma excised previously and the diagnosis is made based on (1) the presence of a carcinoma, and (2) the history of a pleomorphic adenoma at that location.
- Di Palma, S. (Jul 2013). "Carcinoma ex pleomorphic adenoma, with particular emphasis on early lesions". Head Neck Pathol. 7 Suppl 1: S68–76. doi:10.1007/s12105-013-0454-z. PMC 3712089. PMID 23821206.
- Antony, J.; Gopalan, V.; Smith, RA.; Lam, AK. (Mar 2012). "Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data". Head Neck Pathol. 6 (1): 1–9. doi:10.1007/s12105-011-0281-z. PMC 3311945. PMID 21744105.