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Community Programs for Clinical Research on AIDS

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The Community Programs for Clinical Research on AIDS (CPCRA) was a programme sponsored by National Institutes of Health (NIH) in the United States.[1][2] It began in 1989, and was instrumental in some research databases being established. Research from the programs assisted the evaluation of therapies for HIV in diverse populations.

History

The CPCRA was established in 1989[3] and included 15 research units. A Statistical Center at the University of Minnesota was funded from 1990 to 1997.[4][5]

The CPCRA was one of four networks that NIH was using to conduct clinical trials that were looking to understand possible therapies for people with HIV infection.[6] Th CPCRA network was community-based with access to diverse populations across the spectrum of HIV diseases..."[7]

The overall objective of the CPCRA is to design studies of sufficient size and duration of follow up to evaluate the long-term benefits and unintended consequences of various treatment strategies using available agents to assess long-term immunologic, virologic and clinical outcomes. CPCRA trials are designed with nested substudies aimed at understanding the pathogenesis of HIV infection and the public health implications of its treatment.[8]

By 2001, CPCRA had 4,244 people participating in their studies, with trials underway in 17 cities.[9]

The International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) biorepository system has its roots in the CPCRA.[10]

Research

An antiretroviral medication self-reporting questionnaire was developed by the programme.[11]

The programme organised the 058 FIRST (Flexible Initial Retrovirus Suppressive Therapies) trial: a large, long-term, randomized, prospective comparison of three different antiretroviral strategies in highly active antiretroviral therapy-naïve, HIV-1-infected persons.[12]

References

  1. ^ [1]
  2. ^ Cox, LE; Rouff, JR; Svendsen, KH; Markowitz, M; Abrams, DI (November 1998). "Community advisory boards: their role in AIDS clinical trials. Terry Beirn Community Programs for Clinical Research on AIDS" (PDF). Health Soc Work. 23 (4): 290–7.
  3. ^ "An inventory of federally sponsored HIV and HIV-relevant databases. Database:Terry Beirn community programs for clinical research on AIDS (CPCRA) observational database (ODB)". Assistant Secretary for Planning and Evaluation (ASPE). 7 January 2000. Retrieved 21 April 2016.
  4. ^ research grant information
  5. ^ [2]
  6. ^ "NIAID Research on AIDS" (Press release). aidsinfo.nih.gov. 1 January 1995. Retrieved 22 April 2016.
  7. ^ [3]
  8. ^ "Archived copy". Archived from the original on July 3, 2007. Retrieved April 17, 2007. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)CS1 maint: archived copy as title (link)
  9. ^ "HIV Infections in Minority Populations" (Press release). aidsinfo.nih.gov. 1 June 2002. Retrieved 22 April 2016.
  10. ^ Huppler Hullsiek, Katherine; George, Michelle; Brown, Shawn K. (November 2010). "Designing and managing a flexible and dynamic biorepository system: a 15 year perspective from the CPCRA, ESPRIT, and INSIGHT clinical trial networks". Curr Opin HIV AIDS. 5 (6): 538–544. doi:10.1097/COH.0b013e32833f2058.
  11. ^ Mannheimer, Sharon; Friedland, Gerald; Matts, John; Child, Carroll; Chesney, Margaret (2002). "The Consistency of Adherence to Antiretroviral Therapy Predicts Biologic Outcomes for Human Immunodeficiency Virus—Infected Persons in Clinical Trials". Clinical Infectious Diseases. 34: 1115–21. doi:10.1086/339074.
  12. ^ MacArthur, RD; Chen, L; Mayers, DL; Besch, CL; Novak, R; van den Berg-Wolf, M; Yurik, T; Peng, G; Schmetter, B; Brizz, B; Abrams, D (April 2001). "The rationale and design of the CPCRA (Terry Beirn Community Programs for Clinical Research on AIDS) 058 FIRST (Flexible Initial Retrovirus Suppressive Therapies) trial". Control Clin Trials. 22: 176−90. doi:10.1016/S0197-2456(01)00111-8.


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