ctRNA
| ctRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of ctRNA_p42d | |
| Identifiers | |
| Symbol | ctRNA_p42d |
| Rfam | RF00489 |
| Other data | |
| RNA type | Gene; antisense |
| Domain(s) | Bacteria |
| SO | SO:0000644 |
| PDB structures | PDBe |
In molecular biology ctRNA (counter-transcribed RNA) is a plasmid encoded noncoding RNA that binds to the mRNA of repB and causes translational inhibition.[1] ctRNA is encoded by plasmids and functions in rolling circle replication to maintain a low copy number. In Corynebacterium glutamicum, it achieves this by antisense pairing with the mRNA of RepB, a replication initiation protein.[1] In Enterococcus faecium the plasmid pJB01 contains three open reading frames, copA, repB, and repC. The pJB01 ctRNA is coded on the opposite strand from the copA/repB intergenic region and partially overlaps an atypical ribosome binding site for repB.[2]
See also
References
- ^ a b Venkova-Canova, T; Patek M; Nesvera J (2003). "Control of rep gene expression in plasmid pGA1 from Corynebacterium glutamicum". J Bacteriol. 185 (8): 2402–2409. doi:10.1128/JB.185.8.2402-2409.2003. PMC 152619. PMID 12670963.
- ^ Kim SW, Jeong IS, Jeong EJ; et al. (July 2008). "The terminal and internal hairpin loops of the ctRNA of plasmid pJB01 play critical roles in regulating copy number". Mol. Cells. 26 (1): 26–33. PMID 18511887.
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External links
- Page for ctRNA_pGA1 at Rfam
- Page for ctRNA_p42d at Rfam
- Page for ctRNA_pND324 at Rfam
- Page for ctRNA_pT181 at Rfam
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