Cyclopentenone prostaglandins
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Cyclopentenone prostaglandin (cyPG) is a type of prostaglandin, a molecule which regulates inflammation and other processes. It is a potential new target for anti-inflammatory actions. It is thought to prevent the inflammatory pathway by inhibiting the activation of NF-κB, a transcription factor in cell reproduction.
The cyclopentenone prostaglandin known as 15d-PGJ2 has been shown to inhibit a gene in T cells which is active in inflammation, such as in various autoimmune diseases.[1][2] 15d-PGJ2 is also demonstrated to suppress hair growth and is implicated in male pattern baldness.[3]
References
- ^ Fionda, C., et al. (2007). Inhibition of Trail gene expression by cyclopentenonic prostaglandin 15-Deoxy-Δ12,14-Prostaglandin J2 in T lymphocytes. Molecular Pharmacology 72:5 1246-57.
- ^ Cernuda-Morollón, E., et al. (2001). 15-Deoxy-Δ12,14-prostaglandin J2 Inhibition of NF-κB-DNA binding through covalent modification of the p50 subunit. Journal of Biological Chemistry 276 35530-36.
- ^ University of Pennsylvania School of Medicine (22 March 2012). "Research identifies inhibitor causing male pattern baldness and target for hair-loss treatments". Retrieved 23 March 2012.
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