Derendorf has an area of 3.34 km2. By 2006, 18.325 people live there. The median age is about 43 years.
Derendorf was mentioned as a settlement first time in 1100. In 1384 Derendorf became a part of Düsseldorf. There has been a slaughterhouse in Derendorf since 1602. The main growth of Derendorf was in the time of Industrial Revolution.
Derendorf is traditionally an industrial area of Düsseldorf, inhabited mostly by a working-class population. The steelworks of Rheinmetall, the slaughterhouse and the brewery Schlösser are located here .
Many inhabitants of Derendorf are immigrants from Turkey, and the borough houses the central mosque of the Muslims in Düsseldorf.