DExD/H box proteins
DEAD box, DEAH, and the SKI families of proteins are all referred to as DExD/H box proteins.[1] They are all quite distinct from one another and there is not one protein that belongs to more than one of these families. It is thought that each family may have a specific role in RNA metabolism, for example both DEAD box and DEAH box proteins NTPase activities become stimulated by RNA, but DEAD box proteins specifically hydrolyze ATP whereas DEAH can hydrolyze ATP and other NTPs.[2]
References
- ^ De La Cruz, J.; Kressler, D.; Linder, P. (1999). "Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families". Trends in Biochemical Sciences. 24 (5): 192–198. doi:10.1016/S0968-0004(99)01376-6. PMID 10322435.
- ^ Tanner, N.; Cordin, O.; Banroques, J.; Doère, M.; Linder, P. (2003). "The Q motif: A newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis". Molecular Cell. 11 (1): 127–138. doi:10.1016/S1097-2765(03)00006-6. PMID 12535527.
See also
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