David James (cell biologist)

David Ernest James (born Sydney 1958) is a cell biologist who discovered the glucose transporter GLUT4. He has also been responsible for the molecular dissection of the intracellular trafficking pathways that regulate GLUT4 translocation to the cell surface, the topological mapping of the insulin signal transduction pathway, the creation of a method for studying in vivo metabolism in small animals, and the use of this method to gain insights into whole-animal fuel metabolism and homeostasis.

In 1979 he graduated with a BSc (Hons) from the University of New South Wales, and completed his PhD at the Garvan Institute of Medical Research in 1984.

He is currently holds joint appointments at the Garvan Institute and UNSW Australia.

Selected publications

1. James DE, Brown R, Navarro J, Pilch PF (May 1988). "Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein". Nature. 333 (6169): 183–5. doi:10.1038/333183a0. PMID 3285221.
2. James DE, Strube M, Mueckler M (March 1989). "Molecular cloning and characterization of an insulin-regulatable glucose transporter". Nature. 338 (6210): 83–7. doi:10.1038/338083a0. PMID 2645527.
3. Slot JW, Geuze HJ, Gigengack S, Lienhard GE, James DE (April 1991). "Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat". J. Cell Biol. 113 (1): 123–35. doi:10.1083/jcb.113.1.123. PMC 2288909. PMID 2007617.
4. Govers R, Coster AC, James DE (July 2004). "Insulin Increases Cell Surface GLUT4 Levels by Dose Dependently Discharging GLUT4 into a Cell Surface Recycling Pathway". Mol. Cell. Biol. 24 (14): 6456–66. doi:10.1128/MCB.24.14.6456-6466.2004. PMC 434240. PMID 15226445.
5. Larance M, Ramm G, Stöckli J, van Dam EM, Winata S, Wasinger V, Simpson F, Graham M, Junutula JR, Guilhaus M, James DE (November 2005). "Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking". J. Biol. Chem. 280 (45): 37803–13. doi:10.1074/jbc.M503897200. PMID 16154996.{{cite journal}}: CS1 maint: unflagged free DOI (link)
6. Ng Y, Ramm G, Lopez JA, James DE (April 2008). "Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes". Cell Metab. 7 (4): 348–56. doi:10.1016/j.cmet.2008.02.008. PMID 18396141.
7. Yip MF, Ramm G, Larance M, Hoehn KL, Wagner MC, Guilhaus M, James DE (November 2008). "CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes". Cell Metab. 8 (5): 384–98. doi:10.1016/j.cmet.2008.09.011. PMID 19046570.
8. Hoehn KL, Hohnen-Behrens C, Cederberg A, Wu LE, Turner N, Yuasa T, Ebina Y, James DE (May 2008). "IRS1-Independent Defects Define Major Nodes of Insulin Resistance". Cell Metab. 7 (5): 421–33. doi:10.1016/j.cmet.2008.04.005. PMC 2443409. PMID 18460333.
9. Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE (October 2009). "Insulin resistance is a cellular antioxidant defense mechanism". Proc. Natl. Acad. Sci. USA. 106 (42): 17787–92. doi:10.1073/pnas.0902380106. PMC 2764908. PMID 19805130.

See also

• GLUT 4