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Dehydroaltenusin
Names
IUPAC name
3,7-Dihydroxy-9-methoxy-4a-methylbenzo[c ]chromene-2,6-dione
Identifiers
ChemSpider
InChI=1S/C15H12O6/c1-15-6-12(18)10(16)5-9(15)8-3-7(20-2)4-11(17)13(8)14(19)21-15/h3-6,17-18H,1-2H3
Key: YWYZLBQRCUAQAV-UHFFFAOYSA-N
InChI=1/C15H12O6/c1-15-6-12(18)10(16)5-9(15)8-3-7(20-2)4-11(17)13(8)14(19)21-15/h3-6,17-18H,1-2H3
Key: YWYZLBQRCUAQAV-UHFFFAOYAK
CC12C=C(C(=O)C=C1C3=CC(=CC(=C3C(=O)O2)O)OC)O
Properties
C 15 H 12 O 6
Molar mass
288.255 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Dehydroaltenusin is an inhibitor of mammalian DNA polymerase α.[ 1] It has been isolated from the fungus Alternaria tenuis .[ 1]
References
^ a b Mizushina, Y; Maeda, N; Kuriyama, I; Yoshida, H (2011). "Dehydroaltenusin is a specific inhibitor of mammalian DNA polymerase α". Expert Opinion on Investigational Drugs . 20 (11): 1523–34. doi :10.1517/13543784.2011.619977 . PMID 21923630 .