Dithiobutylamine
Appearance
This article relies largely or entirely on a single source. (July 2023) |
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Names | |
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Preferred IUPAC name
(S)-2-aminobutane-1,4-dithiol | |
Other names
DTBA
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Identifiers | |
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3D model (JSmol)
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ChemSpider | |
PubChem CID
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Properties | |
C4H11NS2 | |
Molar mass | 137.26 g/mol |
Appearance | White solid[1] |
Odor | Nearly odorless[1] |
Soluble | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Dithiobutylamine (DTBA) is a reducing agent intended as an alternative for DTT in biochemical uses. It was designed to be easily synthesized in non-racemic form, to have a lower pKa (allowing more effective reduction at neutral pH), and to have a low disulfide E°′ reduction potential.[1] It was rationally designed & reported in 2012.[1] It is commercially available.
See also
[edit]- Dithiothreitol (DTT)
- 2-Mercaptoethanol (BME)
- TCEP
References
[edit]- ^ a b c d e Lukesh, John C.; Palte, Michael J.; Raines, Ronald T. (2012-02-21). "A Potent, Versatile Disulfide-Reducing Agent from Aspartic Acid". Journal of the American Chemical Society. 134 (9). American Chemical Society (ACS): 4057–4059. doi:10.1021/ja211931f. ISSN 0002-7863. PMC 3353773. PMID 22353145.