Staphylopine dehydrogenase

In enzymology, a staphylopine synthase (EC 1.5.1.52) is an enzyme that catalyzes NADPH-dependent reductive condensation of pyruvate to the intermediate (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate, which is the last step in the biosynthesis of the metallophore staphylopine.^[1] The chemical reaction is:

H₂O + NADP⁺ + staphylopine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H⁺ + NADPH + pyruvate^[2]

Alternative name(s): staphylopine dehydrogenase.

References

^ Ghssein, G.; Brutesco, C.; Ouerdane, L.; Fojcik, C.; Izaute, A.; Wang, S.; Hajjar, C.; Lobinski, R.; Lemaire, D.; Richaud, P.; Voulhoux, R. (2016-05-26). "Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus" (PDF). Science. 352 (6289): 1105–1109. Bibcode:2016Sci...352.1105G. doi:10.1126/science.aaf1018. ISSN 0036-8075. PMID 27230378. S2CID 5525387.
^ "cntM – Staphylopine synthase – Staphylococcus aureus (strain Mu50 / ATCC 700699) – cntM gene & protein". www.uniprot.org. Retrieved 2019-12-03.

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[1] Ghssein, G.; Brutesco, C.; Ouerdane, L.; Fojcik, C.; Izaute, A.; Wang, S.; Hajjar, C.; Lobinski, R.; Lemaire, D.; Richaud, P.; Voulhoux, R. (2016-05-26). "Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus" (PDF). Science. 352 (6289): 1105–1109. Bibcode:2016Sci...352.1105G. doi:10.1126/science.aaf1018. ISSN 0036-8075. PMID 27230378. S2CID 5525387.

[2] "cntM – Staphylopine synthase – Staphylococcus aureus (strain Mu50 / ATCC 700699) – cntM gene & protein". www.uniprot.org. Retrieved 2019-12-03.

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