Disodium ribonucleotides

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Disodium 5'-ribonucleotides, E number E635, is a flavor enhancer which is synergistic with glutamates in creating the taste of umami. It is a mixture of disodium inosinate (IMP) and disodium guanylate (GMP) and is often used where a food already contains natural glutamates (as in meat extract) or added monosodium glutamate (MSG). It is primarily used in flavored noodles, snack foods, chips, crackers, sauces and fast foods. It is produced by combining the sodium salts of the natural compounds guanylic acid (E626) and inosinic acid (E630).

Guanylates and inosinates can be found in animal and also plant. While for commercial product, they are produced by fermentation process with raw material from plant origin.

A mixture of 98% monosodium glutamate and 2% E635 has four times the flavor enhancing power of monosodium glutamate (MSG) alone.[1]

Side effects and Safety[edit]

Disodium 5'-ribonucleotides were first assessed in 1974 by the Joint FAO/WHO Expert Committee on Food Additives based on all available scientific literature. This assessment resulted in a new specification prepared and an "ADI Not Specified".[2] This essentially means that this additive shows no toxicology at any level and acceptable daily limits do not need to be set. The definition is as follows:

“This statement means that, on the basis of available data (chemical, biochemical, and toxicological), the total daily intake of the substance arising from its use or uses at levels necessary to achieve the desired effect and from its acceptable background in food, does not, in the opinion of the Committee, represent a hazard to health. For this reason, and for reasons stated in the individual evaluations, the establishment of an acceptable daily intake (ADI) expressed in mg per kg of body weight is not deemed necessary.”

In 1993 the Joint FAO/WHO Expert Committee on Food Additives considered several more studies on this food additive and retained the "ADI not specified" safety classification.

Dietary Restrictions[edit]

Nowadays, Guanylates and inosinates are generally produced through fermentation process from plant raw material such as tapioca starch. They are thus suitable for vegans and vegetarians. Besides, they are also suitable for Jews, Muslims and Hindus, depending on the origin of the product.

See also[edit]


  1. ^ 5'-Ribonucleotides at chemicalland21.com
  2. ^ [1] JECFA Reports WHO Technical Report Series (TRS)