Indisulam

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Indisulam
Indisulam.svg
Names
Preferred IUPAC name
N1-(3-Chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
Other names
E7070
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
KEGG
UNII
  • InChI=1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
    Key: SETFNECMODOHTO-UHFFFAOYSA-N
  • C1=CC2=C(C(=C1)NS(=O)(=O)C3=CC=C(C=C3)S(=O)(=O)N)NC=C2Cl
Properties
C14H12ClN3O4S2
Molar mass 385.84 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Indisulam is a chloroindolyl sulfonamide cell cycle inhibitor that exhibits antitumor activity in vitro and in an animal model.[1][2][3] This compound affects cell cycle progression in human tumor cells and is being studied for the treatment of cancers such as melanomas and blood-borne cancers such as leukemia.[4]

References[edit]

  1. ^ Fukuoka, K., Usuda, J., Iwamoto, Y. et al. . (2001). "Mechanisms of Action of the Novel Sulfonamide Anticancer Agent E7070 on Cell Cycle Progression in Human Non-Small Cell Lung Cancer Cells". Invest New Drugs. 19 (3): 219–27. doi:10.1023/A:1010608317361. PMID 11561678. S2CID 26100991.{{cite journal}}: CS1 maint: uses authors parameter (link)
  2. ^ Y, Ozawa; Nh, Sugi; T, Nagasu; T, Owa; T, Watanabe; N, Koyanagi; H, Yoshino; K, Kitoh; K, Yoshimatsu (November 2001). "E7070, a Novel Sulphonamide Agent With Potent Antitumour Activity in Vitro and in Vivo". European Journal of Cancer. 37 (17): 2275–82. doi:10.1016/s0959-8049(01)00275-1. PMID 11677118.
  3. ^ E, Raymond; Ww, ten Bokkel Huinink; J, Taïeb; Jh, Beijnen; S, Faivre; J, Wanders; M, Ravic; P, Fumoleau; Jp, Armand (2002-08-15). "Phase I and Pharmacokinetic Study of E7070, a Novel Chloroindolyl Sulfonamide Cell-Cycle Inhibitor, Administered as a One-Hour Infusion Every Three Weeks in Patients With Advanced Cancer". Journal of Clinical Oncology. 20 (16): 3508–21. doi:10.1200/JCO.2002.09.030. PMID 12177112.
  4. ^ Rita Assi, MD, Hagop M. Kantarjian, MD, Jorge E. Cortes, MD, Tapan Kadia, MD, Naveen Pemmaraju, MD, Elias J. Jabbour, MD, Nitin Jain, MD, Naval Daver, MD, Taisuke Uehara, Takashi Owa, PhD, Gautam Borthakur, MD (2001). "Final Results of Phase 2, Open-Label Study of E7070, Idarubicin and Cytarabine in Patients (Pts) with Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (MDS)". Blood. 130 (supplement 1).{{cite journal}}: CS1 maint: uses authors parameter (link)