EDDHA

EDDHA
Names
	IUPAC name 2-[2-[ [2-Hydroxy-1-(2-hydroxyphenyl)-2-oxoethyl]amino]ethylamino]-2-(2-hydroxyphenyl)acetic acid
	Other names Ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid
Identifiers
CAS Number	1170-02-1 ;
3D model (JSmol)	Interactive image; Interactive image;
ChEMBL	ChEMBL21178 ;
ChemSpider	13782 ;
ECHA InfoCard	100.013.296
PubChem CID	14432;
CompTox Dashboard (EPA)	DTXSID30864677 ;
	InChI InChI=1S/C18H20N2O6/c21-13-7-3-1-5-11(13)15(17(23)24)19-9-10-20-16(18(25)26)12-6-2-4-8-14(12)22/h1-8,15-16,19-22H,9-10H2,(H,23,24)(H,25,26) Key: PZZHMLOHNYWKIK-UHFFFAOYSA-N ; InChI=1/C18H20N2O6/c21-13-7-3-1-5-11(13)15(17(23)24)19-9-10-20-16(18(25)26)12-6-2-4-8-14(12)22/h1-8,15-16,19-22H,9-10H2,(H,23,24)(H,25,26) Key: PZZHMLOHNYWKIK-UHFFFAOYAQ;
	SMILES C1=CC=C(C(=C1)C(C(=O)O)NCCNC(C2=CC=CC=C2O)C(=O)O)O; O=C(O)C(NCCNC(c1ccccc1O)C(=O)O)c2ccccc2O;
Properties
Chemical formula	C18H20N2O6
Molar mass	360.3612
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

EDDHA or ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid) is an iron-chelating chemical used in bacterial siderophore studies.^[1]^[2]

History

The Fe-EDDHA story starts on December 11, 1953 in Berkeley, California, at a meeting sponsored by Geigy Chemical Corporation. It was at this meeting that Arthur Wallace of UCLA and Harry Kroll of Geigy met on a brain-storming session aimed at dreaming up the structure of a stable iron chelate. ^[3]

The first attempts to make fe-EDDHA commercially and agriculturally viable were made by Dr.Ramesh Patel of Agricon Chemicals,a leading plant nutritiononist and industrialist from India.He was awarded Padma Bhushan for this service to the agricultural world.In India the development, and use of EDDHA, EDTA and other such chelate fertilizers today is largely successful due to the pioneering efforts of such private players in India.

Currently Spain is the world's largest manufacturer of iron chelate EDDHA, being 4.8% ortho-ortho the most exported. Companies like AGRARES have been responsible for the international expansion of the product, notifying the advantages of EDDHA against EDDHSA or EDDHMA.

^[4]

References

^ Diarra MS, Petitclerc D, Lacasse P (2002). "Response of Staphylococcus aureus isolates from bovine mastitis to exogenous iron sources". J. Dairy Sci. 85 (9): 2141–8. doi:10.3168/jds.S0022-0302(02)74292-6. PMID 12362445.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Sritharan M, Asuthkar S (2004). "Iron-regulated proteins (IRPS) of leptospira biflexa serovar Patoc strain Patoc I". Indian journal of medical microbiology. 22 (2): 92–6. PMID 17642703.
^ Micronutrient Bureau 1990 vol No. 1, page 7
^ The Modern Agriculture Journal Published by the Government of India,2008

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[1] Diarra MS, Petitclerc D, Lacasse P (2002). "Response of Staphylococcus aureus isolates from bovine mastitis to exogenous iron sources". J. Dairy Sci. 85 (9): 2141–8. doi:10.3168/jds.S0022-0302(02)74292-6. PMID 12362445.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[2] Sritharan M, Asuthkar S (2004). "Iron-regulated proteins (IRPS) of leptospira biflexa serovar Patoc strain Patoc I". Indian journal of medical microbiology. 22 (2): 92–6. PMID 17642703.

[3] Micronutrient Bureau 1990 vol No. 1, page 7

[4] The Modern Agriculture Journal Published by the Government of India,2008

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