Epstein–Barr virus small nucleolar RNA 1
|Human herpesvirus 1 small nucleolar RNA|
Sequence concservation of v-snoRNA1
V-snoRNA1 is a box CD-snoRNA[clarification needed] identified in B lymphocytes infected with the Epstein–Barr virus (human herpesvirus 4 (HHV-4)). This snoRNA is the first known example of a snoRNA expressed from a viral genome. It is homologous to eukaryotic snoRNAs because it contains the C and D boxes sequence motifs[clarification needed] but lacks a terminal stem-loop structure. The nucleolar localization of v-snoRNA1 was determined by in situ hybridization. V-snoRNA1 can form into a ribonucleoprotein complex (snoRNP) as co-immunoprecipitation (CoIP) assays showed that this snoRNA interacts with the snoRNA core proteins, fibrillarin, Nop56, Nop58.[clarification needed] It has also been proposed that this snoRNA may act as a miRNA-like precursor that is processed into 24-nucleotide-sized RNA fragments that target the 3'UTR[clarification needed] of viral DNA polymerase mRNA.
- Hutzinger, R.; Feederle, R.; Mrazek, J.; Schiefermeier, N.; Balwierz, J.; Zavolan, M.; Polacek, N.; Delecluse, J.; Hüttenhofer, A. (Aug 2009). Cullen, Bryan R, ed. "Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome" (Free full text). PLoS Pathogens. 5 (8): e1000547. ISSN 1553-7366. PMC . PMID 19680535. doi:10.1371/journal.ppat.1000547.
- Gardner, P. P.; Bateman, A.; Poole, A. M. (2010). "SnoPatrol: How many snoRNA genes are there?". Journal of Biology. 9 (1): 4. PMC . PMID 20122292. doi:10.1186/jbiol211.