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File:Extramammary Paget disease - w cond - very high mag.jpg

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Description
English: Very high magnification micrograph of extramammary Paget's disease, abbreviated EMPD. Vulvar biopsy. H&E stain.

The images show the characteristic large cells with clear cytoplasm in the epidermis. The H&E slide is not definitive; the clear cells may represent:

The definitive diagnosis is determined with immunohistochemical stains (S-100 -ve and HMB-45 -ve (both typically +ve in melanoma), CK7 +ve, CEA +ve (-ve in Bowen's disease, -ve in Toker cells).

The histologic appearance of Paget's disease of the breast is identical to extramammary Paget's disease, i.e. it is not possible to say this is extramammary from the image alone.

  • Low mag.
    Low mag.
  • Intermed mag.
    Intermed mag.
  • High mag.
    High mag.
  • Very high mag.
    Very high mag.
  • Very high mag.
    Very high mag.
Source Own work
Author Nephron

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Date/TimeThumbnailDimensionsUserComment
current05:33, 27 August 2011Thumbnail for version as of 05:33, 27 August 20112,848 × 4,272 (3.54 MB)Nephron{{Information |Description ={{en|1=Very high magnification micrograph of '''extramammary Paget's disease''', abbreviated '''EMPD'''. Vulvar biopsy. H&E stain.

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