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Overview of the miRNAs biogenesis. In the canonical pathway in the nucleus, pri-miRNAs are cleaved into pre-miRNAs by Drosha. Pre-miRNAs are exported to the cytoplasm by exportin 5. In the cytoplasm, pre-miRNAs are cleaved into small dsRNAs by Dicer. Then, RISC mediates the recognition of the mRNA to be targeted. In the non-canonical pathway (Mirtron), Drosha cleavage is substituted with splicing. pri-miRNAs (pre-mRNAs) are processed to pre-miRNAs by the spliceosome machinery and debranching enzyme to generate double-stranded loop structures like the regular miRNAs. Subsequently, the RNA product of splicing adopts a pre-miRNA like form, and transferred to the cytoplasm by exportin 5 to continue with the canonical pathway. For more details please refer to the text.

Summary

Description
English: Diagram of microRNA. Based on [1], [2], [3], the wikipedia article, and various other sources.
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Author Kelvinsong
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Go to this template page for this block Go to the editable text version of this picture transcription · transcription  
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Go to the editable text version of this picture micro rna · micro arn · микроРНК  
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Go to the editable text version of this picture lac operon · opéron lactose  
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Captions

A schematic showing the formation and function of micro RNA.

Items portrayed in this file

depicts

inception

23 December 2012

File history

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Date/TimeThumbnailDimensionsUserComment
current10:23, 19 May 2019Thumbnail for version as of 10:23, 19 May 20192,181 × 1,226 (1,006 KB)JoKalliauerhttps://commons.wikimedia.org/wiki/Commons:Help_desk#Found_unsafe_CSS_in_the_style_element_of_uploaded_SVG_file Please delete src: url("data:font/woff;charset=utf-8;base64,data:application/x-font-ttf;base64
02:06, 24 December 2012Thumbnail for version as of 02:06, 24 December 20122,181 × 1,226 (1.58 MB)IsadoraofIbizaremove confusing sentence
02:01, 24 December 2012Thumbnail for version as of 02:01, 24 December 20122,181 × 1,226 (1.64 MB)IsadoraofIbizamoving text around
01:49, 24 December 2012Thumbnail for version as of 01:49, 24 December 20122,181 × 1,226 (1.63 MB)IsadoraofIbizaadjusted number position
01:46, 24 December 2012Thumbnail for version as of 01:46, 24 December 20122,181 × 1,226 (1.63 MB)IsadoraofIbizaUser created page with UploadWizard

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