Jump to content

File:Putative mechaism of action of Human IRGM.jpg

Page contents not supported in other languages.
This is a file from the Wikimedia Commons
From Wikipedia, the free encyclopedia

Putative_mechaism_of_action_of_Human_IRGM.jpg (688 × 511 pixels, file size: 40 KB, MIME type: image/jpeg)

Summary

Description
English: Figure5: Under conditions of moderate to low expression levels, IRGMs constantly survey for signals such as pathogen entry, starvation or increase in levels of IFNγ.Upon encounter with pathogen, mitochondrial fission pathways are turned on leading to autophagy ,microbial clearance promoting host cell survival. When highly expressed,IRGM binds to mitochondrial membrane bound lipid, cardiolipin and translocates into mitochondria which leads to depolarization and loss of mitochondrial membrane potential. This stimulates autophagy independent but pro-apoptotic factors bax/Bak dependent host cell death.
Date
Source Own work
Author 2011MMG320group2

Adapted from PMID 21102437

Licensing

I, the copyright holder of this work, hereby publish it under the following license:
Creative Commons CC-Zero This file is made available under the Creative Commons CC0 1.0 Universal Public Domain Dedication.
The person who associated a work with this deed has dedicated the work to the public domain by waiving all of their rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law. You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission.

Captions

Add a one-line explanation of what this file represents

Items portrayed in this file

depicts

27 April 2011

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current09:12, 28 April 2011Thumbnail for version as of 09:12, 28 April 2011688 × 511 (40 KB)2011MMG320group2{{Information |Description ={{en|1= Figure5: Under conditions of moderate to low expression levels, IRGMs constantly survey for signals such as pathogen entry, starvation or increase in levels of IFNγ.Upon encounter with pathogen, mitochondrial fissio

The following 2 pages use this file:

Metadata